Are SSRIs associated with upper gastrointestinal bleeding in adults?
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Selective serotonin reuptake inhibitor (SSRI) use is associated with a 2-fold increase in the incidence of upper gastrointestinal bleeding. Concomitant use of aspirin or nonsteroidal anti-inflammatory drugs (NSAIDs) with SSRIs increases the risk of upper gastrointestinal bleeding even further. (SOR B, based on a meta-analysis and systematic reviews of case-control studies.)
Evidence-based practice 13, no. 03 (2010): 06-07