What are the best antivirals for the treatment of influenza?
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Oseltamivir reduces mortality due to influenza in hospitalized patients (SOR B, based on a cohort study) and complication rates in otherwise healthy adults (SOR A, based on a meta-analysis). Both neuraminidase inhibitors oseltamivir and zanamivir reduce the severity and duration of influenza A and B symptoms. (SOR A, based on systematic reviews.) The adamantanes (amantadine and rimantadine) reduce the duration of influenza A; rimantadine is better tolerated than amantadine. (SOR A, based on a meta-analysis.)
Evidence Based Practice 13(3): 08.