What is the best treatment for ACE-inhibitor-related cough?
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When angiotensin-converting enzyme (ACE)-inhibitor-related cough precludes continued therapy, the need to block the renin-angiotensin system should be reassessed. If this is a key component of therapy, an angiotensin receptor blocker (ARB) is an effective alternative. (SOR A, based on several large randomized controlled trials [RCTs].) If this is not an option, a reduction in cough may be attempted by switching to another ACE inhibitor, or by the addition of nonsteroidal anti-inflammatory drugs (NSAIDs), calcium channel blockers, ferrous sulfate, or other medications. (SOR C, based on expert opinion.)
Evidence Based Practice 13(3): 07.