What is the best treatment for Graves' disease in women trying to become pregnant?

Abstract

It is recommended that pregnant women with Graves' disease and thyroid-stimulating hormone (TSH) antibodies be treated with an antithyroid drug, whereas those without TSH antibodies should simply be observed. Radioiodine treatment with iodine-131 (I-131) is contraindicated when a woman is attempting pregnancy and during pregnancy. Propylthiouracil (PTU) is the first-line drug therapy during the first trimester. (SOR B, from an evidence-based guideline.)