What interventions improve outcomes for patients with isolated low levels of high-density lipoprotein (HDL)?
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While an epidemiologic link between low HDL and cardiovascular risk exists, efforts to raise HDL have no significant effect on cardiovascular disease (CVD) or cardiovascular mortality after controlling for their simultaneous effect on lowering low-density lipoprotein (LDL). (SOR A, based on systematic review of RCTs.)
Evidence Based Practice 13(4): 07.