What is the best starting dose when initiating warfarin?
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A loading protocol with 10 mg warfarin on days 1 and 2 achieves rapid therapeutic international normalized ratios (INRs) without significantly increasing harmful complications. However, in special populations, such as the elderly, a lower initiation dose is recommended. (SOR C, based on heterogeneous randomized controlled trials.)
Evidence Based Practice 13(4): 08-10.