Bupropion for SSRI-induced sexual dysfunction in women
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For selective serotonin reuptake inhibitor (SSRI)-induced sexual dysfunction in women, bupropion sustained-release (SR) 150 mg twice daily is similar to placebo in its effect on most measures of sexual function and interest, but is more likely to improve sexual desire, as indicated by an increase in the frequency of sexual activity. Patients taking bupropion SR reported more dry mouth, headache, and irritability, but also less anxiety, stress, fatigue, and mood lability than patients taking placebo. (SOR C, based on extrapolation of data from a single randomized trial.)
Evidence Based Practice 13(5): 14.