What is the best prophylactic treatment for chronic tension headaches?
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For prophylaxis of chronic tension-type headache, the tetracyclic antidepressant mirtazapine is more effective than amitriptyline and has fewer adverse effects. (SOR B, based on small, but consistent RCTs.) Selective serotonin reuptake inhibitors (SSRIs) are less effective than tricyclic antidepressants (TCAs). (SOR A, based on a meta-analysis.)
Evidence-based practice 13, no. 05 (2010): 12-13