What is the best treatment for the pain of acute herpes zoster?
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Valacyclovir is more effective for the acute pain of herpes zoster than acyclovir. Oxycodone provides additional acute pain relief for patients taking antiviral medication, but is associated with substantial adverse effects. Gabapentin is ineffective in managing acute herpes zoster. (SOR B, based on individual RCTs.)
Evidence Based Practice 13(5): 11.