Should antibiotic prophylaxis be used for cirrhotic patients hospitalized with gastrointestinal bleeding?
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Antibiotic prophylaxis in cirrhotic patients with upper gastrointestinal bleeding (UGIB) significantly reduces the incidence of bacterial infections and mortality for up to 30 days of follow-up. (SOR A, based on a systematic review.) Norfloxacin for 7 days is recommended (SOR C, based on consensus guidelines), although local resistance patterns may make other antibiotics more effective. (SOR C, extrapolated from a single comparative RCT.)
Evidence-based practice 13, no. 06 (2010): 09