Should antibiotic prophylaxis be used for cirrhotic patients hospitalized with gastrointestinal bleeding?
Metadata[+] Show full item record
Antibiotic prophylaxis in cirrhotic patients with upper gastrointestinal bleeding (UGIB) significantly reduces the incidence of bacterial infections and mortality for up to 30 days of follow-up. (SOR A, based on a systematic review.) Norfloxacin for 7 days is recommended (SOR C, based on consensus guidelines), although local resistance patterns may make other antibiotics more effective. (SOR C, extrapolated from a single comparative RCT.)
Evidence Based Practice 13(6): 09.