What are the most effective and safest pharmacologic treatments for adults with chronic, primary insomnia?
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Benzodiazepines (BZDs), nonbenzodiazepine hypnotics (non-BZDs), and antidepressants effectively improve sleep onset latency (SOL), wake time after sleep onset (WASO), and total sleep time (TST). (SOR A, based on systematic review/meta-analysis.) Selective melatonin receptor agonists effectively improve SOL, but do not improve WASO or TST. (SOR A, based on RCT.)
Evidence Based Practice 13(6): 04-06.