Isolated elevation of maternal human chorionic gonadotropin (hCG) associated with adverse fetal outcomes
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Evidence clearly indicates an increased risk of adverse outcomes (including fetal loss, preterm birth, intrauterine growth restriction [IUGR], fetal macrosomia, and preeclampsia) with a second-trimester hCG level more than 3 multiples of the median, even in the presence of normal ultrasound and chromosome analysis. Women should be counseled about these risks. Some experts recommend that women in this situation be offered antenatal testing for fetal well-being beginning at 32 weeks.
Evidence Based Practice 13(7): 13.