• Introduction to Clinical Inquiries : new series by the Family Physicians Inquiries Network 

  Mott, Timothy; Guthmann, Richard (Family Physicians Inquiries Network, 2020)

  Introduction to Clinical Inquiries and FPIN. The Clinical Inquiries were included in Canadian Family Physician beginning March 2020.

• Acupuncture for low back pain 

  Clemente Fuentes, Roselyn; Organ, Brooke; Creech, Julie; Broszko, Christine M.; Nashelsky, Joan (Family Physicians Inquiries Network, 2020)

  Clinical Inquiries question: Is acupuncture effective in improving pain relief for low back pain? Evidence-based answer: Acupuncture is an effective treatment for relief from low back pain, even when compared with other ...

• Efficacy of a low-carbohydrate or ketogenic diet in preventing patient morbidity and mortality 

  Clemente Fuentes, Roselyn W.; Broszko, Christine M.; Pietralcyzk, Elizabeth S.; Nashelsky, Joan (Family Physicians Inquiries Network, 2020)

  Clinical Inquiries question: What is the efficacy of a low-carbohydrate or ketogenic diet in the prevention of patient morbidity and mortality? Evidence-based answer: Ketogenic diets can reduce seizure incidence in refractory ...

• Hypoglycemia with insulin and sulfonylureas 

  Kolman, Karyn B.; Freeman, Joshua; Howe, Carol L. (Family Physicians Inquiries Network, 2020)

  Clinical Inquiries question: In patients with type 2 diabetes mellitus (T2DM), does the combination of insulin and sulfonylurea (SU) increase the risk of hypoglycemia? Evidence-based answer: The incidence of severe ...

• Chlamydia test-of-cure in pregnancy 

  Pettit, Jessie; Howe, Carol; Freeman, Joshua (Family Physicians Inquiries Network, 2020)

  Clinical Inquiries question: What is the optimal interval between treatment and test-of-cure (TOC) in pregnant women with Chlamydia trachomatis (CT)? Evidence-based answer: The optimal interval between treatment and TOC ...

• Effect of corticosteroids on pain and function in knee osteoarthritis patients 

  Beggs, Luke; Stigleman, Sue; Vaughan, Aaron; Pacious, Josh; Hulkower, Stephen (Family Physicians Inquiries Network, 2020)

  Clinical Inquiries question: Does the type of corticosteroid have an effect on pain and functional status of the knee in osteoarthritis (OA) patients receiving intra-articular injections? Evidence-based answer: In patients ...

• Effective analgesic options for intrauterine device placement pain 

  Whitworth, Karena; Neher, Jon; Safranek, Sarah (Family Physicians Inquiries Network, 2020)

  Clinical Inquiries question: What analgesic options are most effective for pain related to intrauterine device (IUD) placement? Evidence-based answer: Lidocaine-prilocaine cream (LPC; 2.5% lidocaine and 2.5% prilocaine) ...

• Potential harms of long-term acne treatment with oral antibiotics 

  Dao, Minh; Kelsberg, Gary; Louden, Diana (Family Physicians Inquiries Network, 2020)

  Clinical Inquiries question: What are the potential harms of long-term acne treatment with oral antibiotics? Evidence-based answer: Specific evidence attributing adverse effects to long-term acne treatment with oral ...

• Effectiveness of dermoscopy in skin cancer diagnosis 

  Davis, Sydney; Piggot, Cleveland; Lyon, Corey; DeSanto, Kristen (Family Physicians Inquiries Network, 2020)

  Clinical Inquiries question: Does dermoscopy improve the effectiveness of skin cancer diagnosis when used for skin cancer screening? Evidence-based answer: Dermoscopy added to visual inspection is more accurate than visual ...

• Platelet-rich plasma injection for rotator cuff disease 

  Loescher, Jeremy; Guthmann, Richard; Auten, Beth (Family Physicians Inquiries Network, 2020)

  Clinical Inquiries question: Is platelet-rich plasma (PRP) injection an effective treatment for rotator cuff disease? Evidence-based answer: In non-operative treatment of rotator cuff injuries, PRP injection did not improve ...

• Association of first-line antidepressants and incident adverse metabolic effects 

  Wen, Frances K.; Crosby, Kimberly; Miller, Barbara H.; Rommen, Michael; Kirzner, Samuel J.; Hoberecht, Toni; Migdalski, Alyssa (Family Physicians Inquiries Network, 2020)

  Clinical Inquiries question: Are first-line antidepressants associated with incident adverse metabolic effects in adults? Evidence-based answer: Selective serotonin reuptake inhibitors (SSRIs) and bupropion statistically ...

• Does vitamin D supplementation reduce asthma exacerbations? 

  Jaura, Jaspreet; Kelsberg, Gary; Safranek, Sarah (Family Physicians Inquiries Network, 2020)

  Q: Does vitamin D supplementation reduce asthma exacerbations? Evidence-based answer: YES, to some extent it does, and primarily in patients with low vitamin D levels. Supplementation reduces asthma exacerbations requiring ...

• Do prophylactic antipyretics reduce vaccination-associated symptoms in children? 

  Chau-Glendinning, Hang; Baber, Blair; Neher, Jon O.; Safranek, Sarah (Family Physicians Inquiries Network, 2020)

  Q: Do prophylactic antipyretics reduce vaccination-associated symptoms in children? Yes for acetaminophen, not so much for ibuprofen. Prophylactic acetaminophen reduces the odds of febrile reactions in the first 48 hours ...

• Does XR injectable naltrexone prevent relapse as effectively as daily sublingual buprenorphine-naloxone? 

  Roe, Matthew; Wilson, Courtenay Gilmore; Fusco, Carriedelle Wilson; Hulkower, Stephen; Stigleman, Sue (Family Physicians Inquiries Network, 2020)

  Q: Does XR injectable naltrexone prevent relapse as effectively as daily sublingual buprenorphine-naloxone? Evidence-based answer: Yes. Monthly extended-release injectable naltrexone (XR-NTX) treats opioid use disorder as ...

• Do electronic reminder systems help patients with T2DM to lose weight? 

  Kwan, William; Neher, Jon O.; Safranek, Sarah (Family Physicians Inquiries Network, 2020)

  Q: Do electronic reminder systems help patients with T2DM to lose weight? Evidence-based answer: PROBABLY NOT--but they may augment self-management. Four-component telehealth systems--including electronic reminders, measuring ...

• Does early introduction of peanuts to an infant's diet reduce the risk for peanut allergy? 

  Jungwirth, Greg; Stock, Kevin; Neher, Jon O.; Safranek, Sarah (Family Physicians Inquiries Network, 2020)

  Q: Does early introduction of peanuts to an infant's diet reduce the risk for peanut allergy? Evidence-based answer: Probably not, unless the child has severe eczema or egg allergy. In a general pediatric population, ...

• Does evidence support the use of supplements to aid in BP control? 

  Gibbs, Lawrence M.; Nair, Rajasree J.; Nashelsky, Joan (Family Physicians Inquiries Network, 2020)

  Q: Does evidence support the use of supplements to aid in BP control? Evidence-based answer: Yes. A number of well-tolerated natural therapies have been shown to reduce systolic and diastolic blood pressure (BP). (See ...

• Which medications work best for menorrhagia? 

  Lale, Allison; Halajian, Elise; Guthmann, Rick; Nashelsky, Joan (Family Physicians Inquiries Network, 2020)

  Q: Which medications work best for menorrhagia? Evidence-based answer: Four medications have been shown to reduce menstrual blood loss (MBL) significantly in placebo-controlled randomized controlled trials (RCTs): the ...

• Does concurrent use of clopidogrel and PPIs increase CV risk in patients with ACS? 

  Shehata, Sandy; Baker, Jason; Kelsberg, Gary; Safranek, Sarah (Family Physicians Inquiries Network, 2020)

  Q: Does concurrent use of clopidogrel and PPIs increase CV risk in patients with ACS? Evidence-based answer: No. Adding a proton pump inhibitor (PPI) in patients taking antiplatelet medications such as clopidogrel for acute ...

• Do cinnamon supplements improve glycemic control in adults with T2DM? 

  Careyva, Beth; Greenberg, Grant; Jabbour, Katarzyna; Defenbaugh, Nicole; Nashelsky, Joan (Family Physicians Inquiries Network, 2020)

  Q: Do cinnamon supplements improve glycemic control in adults with T2DM? Evidence-based answer: the answer isn't clear. Cinnamon supplements for adults with type 2 diabetes haven't been shown to decrease hemoglobin A1C ...

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