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    Does vitamin D supplementation reduce asthma exacerbations?

    Jaura, Jaspreet
    Kelsberg, Gary
    Safranek, Sarah
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    [PDF] JFP06905e4.pdf (84.03Kb)
    Date
    2020
    Format
    Article
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    Abstract
    Q: Does vitamin D supplementation reduce asthma exacerbations? Evidence-based answer: YES, to some extent it does, and primarily in patients with low vitamin D levels. Supplementation reduces asthma exacerbations requiring systemic steroids by 30% overall in adults and children with mild-to-moderate asthma (number needed to treat [NNT] = 7.7). The outcome is driven by the effect in patients with vitamin D levels < 25 nmol/L (NNT = 4.3), however; supplementation doesn't decrease exacerbations in patients with higher levels. Supplementation also reduces, by a smaller amount (NNT = 26.3), the odds of exacerbations requiring emergency department care or hospitalization (strength of recommendation [SOR]: A, meta-analysis of randomized controlled trials [RCTs]). In children, vitamin D supplementation may also reduce exacerbations and improve symptom scores (SOR: C, low-quality RCTs). Vitamin D doesn't improve forced expiratory volume in 1 second (FEV1) or standardized asthma control test scores. Also, it isn't associated with serious adverse effects (SOR: A, meta-analysis of RCTs).
    URI
    https://hdl.handle.net/10355/79184
    Part of
    Journal of family practice, 69, no. 04 (May 2020): E4-E6
    Rights
    OpenAccess.
    This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License.
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    • Clinical Inquiries, 2020

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