dc.contributor.author | Jaura, Jaspreet | eng |
dc.contributor.author | Kelsberg, Gary | eng |
dc.contributor.author | Safranek, Sarah | eng |
dc.date.issued | 2020 | eng |
dc.description.abstract | Q: Does vitamin D supplementation reduce asthma exacerbations? Evidence-based answer: YES, to some extent it does, and primarily in patients with low vitamin D levels. Supplementation reduces asthma exacerbations requiring systemic steroids by 30% overall in adults and children with mild-to-moderate asthma (number needed to treat [NNT] = 7.7). The outcome is driven by the effect in patients with vitamin D levels < 25 nmol/L (NNT = 4.3), however; supplementation doesn't decrease exacerbations in patients with higher levels. Supplementation also reduces, by a smaller amount (NNT = 26.3), the odds of exacerbations requiring emergency department care or hospitalization (strength of recommendation [SOR]: A, meta-analysis of randomized controlled trials [RCTs]). In children, vitamin D supplementation may also reduce exacerbations and improve symptom scores (SOR: C, low-quality RCTs). Vitamin D doesn't improve forced expiratory volume in 1 second (FEV1) or standardized asthma control test scores. Also, it isn't associated with serious adverse effects (SOR: A, meta-analysis of RCTs). | eng |
dc.description.bibref | Includes bibliographical references | eng |
dc.description.sponsorship | Jaspreet Jaura, MD; Gary Kelsberg, MD (Valley Family Medicine Residency, University of Washington at Valley Medical Center, Renton); Sarah Safranek, MLIS (University of Washington Health Sciences Library, Seattle) | eng |
dc.format.extent | 3 pages | eng |
dc.identifier.uri | https://hdl.handle.net/10355/79184 | eng |
dc.language | English | eng |
dc.publisher | Family Physicians Inquiries Network | eng |
dc.relation.ispartofcollection | Clinical Inquiries, 2020 (MU) | eng |
dc.relation.ispartofcommunity | University of Missouri--Columbia. School of Medicine. Department of Family and Community Medicine. Family Physicians Inquiries Network | eng |
dc.relation.ispartofseries | Journal of family practice, 69, no. 04 (May 2020): E4-E6 | eng |
dc.rights | OpenAccess. | eng |
dc.rights.license | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License. | eng |
dc.title | Does vitamin D supplementation reduce asthma exacerbations? | eng |
dc.type | Article | eng |