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dc.contributor.advisorBlomquist, Gregory E., 1978-eng
dc.contributor.authorKeith, Monica H.eng
dc.date.issued2020eng
dc.date.submitted2020 Summereng
dc.description.abstractBwa Mawego is a small-scale horticultural community (~500 people) on the island of Dominica that has been the site of a longitudinal health research project for more than 30 years. Cardiovascular diseases and metabolic health are growing local concerns. Here we analyze longitudinal growth data, cardiometabolic metrics, and genome-wide single nucleotide polymorphism (SNP) data from this population to investigate sources of variation in anthropometric and cardiometabolic outcomes. Mixed effect heritability models indicate that (1) variation in body mass index (BMI) is significantly shaped by genetic variation, and (2) variation between longitudinal BMI curves has not been consistently impacted by secular environmental trends from 1997 2017. In order to assess genetic variation in more detail, we first characterize the population structure and admixture in this Caribbean community using high-density SNP data and global reference samples in the Human Genome Diversity Panel. We detect four distinct family clusters and admixture from African, European, and Amerindian ancestral populations that occurred 5-6 generations ago (~130-150 years). Amerindian haplotypes represented in Bwa Mawego associate with deeply diverged lineages in Karitiana and Surui peoples, highlighting the regionally variable nature of admixture throughout the Caribbean and unique historical outcomes in Dominica. Genome-wide association tests of cardiometabolic phenotypes identify a genomic region of interest downstream of the ANK3 gene that associates with BMI in Bwa Mawego, after controlling for confounding variation from ancestral population structure and relatedness. Any functional relationship between ANK3 and BMI is currently uncharacterized, and there is unique potential to further explore complex gene-environment-phenotype landscapes in Bwa Mawego.eng
dc.description.bibrefIncludes bibliographical referenceseng
dc.format.extent1 online resource (vii, 100 pages) ; Illustrationseng
dc.identifier.urihttps://hdl.handle.net/10355/79506
dc.identifier.urihttps://doi.org/10.32469/10355/79506eng
dc.languageEnglisheng
dc.publisherUniversity of Missouri--Columbiaeng
dc.relation.ispartofcommunityUniversity of Missouri--Columbia. Graduate School. Theses and Dissertationseng
dc.rightsOpenAccesseng
dc.rights.licenseThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License. Copyright held by author.
dc.subject.otherAnthropologyeng
dc.titleGenetic variation and health in rural Caribbean villageeng
dc.typeThesiseng
thesis.degree.disciplineAnthropology (MU)eng
thesis.degree.grantorUniversity of Missouri--Columbiaeng
thesis.degree.levelDoctoraleng
thesis.degree.namePh. D.eng


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