Browsing School of Biological Sciences (UMKC) by Thesis Advisor "Mukherji, Mridul"
Now showing items 1-3 of 3
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Epigenetic Regulation Of The HIF Pathway And Novel Therapeutic Opportunities
(2014-08-28)The research presented in this dissertation is aimed at understanding the epigenetic regulation of the HIF pathway and the efficacy of treatment for retinal diseases and hemangioblastomas using HIF pathway inhibitors. ... -
Evaluation Of HIF Inhibitors For The Treatment of Ocular Neovascular Diseases
(2015-06-02)Hypoxia-inducible-factor (HIF)-mediated expression of pro-angiogenic genes under hypoxia is the fundamental cause of pathological neovascularization in ocular diseases and cancers. Thus, the inhibitors of the HIF pathway ... -
Functional Analysis of TET-Family 5-Methylcytosine Dioxygenases in Non-CpG DNA Demethylation
(2023)One of the most widely studied epigenetic marks in DNA is 5-methylcytosine (5mC). Research has indicated that in the mammalian genome around 5-6% of all cytosines are methylated (5mC), with a strong preference for the CpG ...