Browsing School of Biological Sciences (UMKC) by Thesis Advisor "Read, George Sullivan, 1948-"
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Decoupling of HSV1 Vhs protein mRNA decay and translation stimulation functions
(2013)Herpes Simplex Virus Type 1 is a member of the alphaherpesvirinae subfamily within the family Herpesviridae. This virus has both a lytic and latent cycle. Primary infection occurs when the virus enters epithelial cells ... -
The herpes simplex virus virion host shutoff protein is targeted to mRNA cleavage sites through interactions with components of the host translational apparatus
(University of Missouri--Kansas City, 2011-01-20)The virion host shutoff protein (Vhs) is a herpes simplex virus (HSV) protein involved in early shutoff of the host cell. It is a component of the infecting virion, located in the tegument region, that works by rapidly ... -
The Role of Host Translation Initiation Factors eIF4H and eIF4A and the Exon Junction Complex in the Control of mRNA turnover and Translation by the Virion Host Shut off Protein of Herpes Simplex Virus
(2013)During lytic infections, the HSV Vhs endonuclease (UL41) degrades many viral and cellular mRNAs. This endonuclease activity is dependent upon the ability of Vhs to bind the host translation initiation factors eIF4AI/II and ...