Search
Now showing items 1-3 of 3
Functional Analysis of TET-Family 5-Methylcytosine Dioxygenases in Non-CpG DNA Demethylation
(2023)
One of the most widely studied epigenetic marks in DNA is 5-methylcytosine (5mC). Research has indicated that in the mammalian genome around 5-6% of all cytosines are methylated (5mC), with a strong preference for the CpG ...
Epigenetic Regulation Of The HIF Pathway And Novel Therapeutic Opportunities
(2014-08-28)
The research presented in this dissertation is aimed at understanding the epigenetic
regulation of the HIF pathway and the efficacy of treatment for retinal diseases and
hemangioblastomas using HIF pathway inhibitors. ...
Evaluation Of HIF Inhibitors For The Treatment of Ocular Neovascular Diseases
(2015-06-02)
Hypoxia-inducible-factor (HIF)-mediated expression of pro-angiogenic genes under
hypoxia is the fundamental cause of pathological neovascularization in ocular diseases and
cancers. Thus, the inhibitors of the HIF pathway ...