RSS 1.0Division of Cell Biology and Biophysics (UMKC)
The teaching mission of the Division of Cell Biology and Biophysics comprises a variety of undergraduate level biology courses (including general biology, cell biology, developmental biology, microbiology, immunology, anatomy and biophysics), graduate level courses in areas of molecular and cell biology, and specialty courses for health professional students.
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Exploiting the Power of Sleep to Rescue Long-Term Memory Defects in a Drosophila Memory Mutant
(2024)Sleep is a behavior indispensable for life that is evolutionarily conserved throughout the animal kingdom, signifying its importance. Investigations into the function(s) of sleep reveal a vast array of processes influenced ... -
Pregnancy outcomes in females with hidradenitis suppurativa
(2024)A pregnancy datamart was constructed from Cerner Health Facts EMR data using pypreg, a python package developed by the author based on a validated pregnancy identification algorithm by Keran Moll. The demographics of the ... -
Regulation of the development and regeneration of the zebrafish posterior lateral line
(2024)Mechanosensory hair cells located in the inner ear mediate the sensations of hearing and balance. If damaged, mammalian inner ear hair cells are unable to regenerate, resulting in permanent sensory deficits. Damage to hair ... -
Discovery of IKBKE and CD24 siRNAs for the treatment of triple-negative breast cancer
(2023)Triple-negative breast cancer (TNBC) represents approximately 10-20% of all newly diagnosed breast cancers and is classified as a subtype with the absence of ER, PR, and HER2 expression. TNBC displays high aggressiveness, ... -
Identification and Characterization of Two Novel Sleep Promoting Neurons Located in the Ventral Nerve Cord of Drosophila Melanogaster
(2023)Sleep is a phenomenon that is ubiquitous in the animal kingdom and can be found in nearly every evolutionary niche that has come about. Humans cannot live without it, and it is required for optimal physical and mental ... -
Development of Resistance to Antifungal Agents in Common Yeast Species
(2018)Pathogenic fungi are responsible for several serious diseases in both plants and animals with severe consequences in both medicine and agriculture. This makes treatment of fungal infections a prime concern for both economic ... -
The Ins and Outs and ABCs of Antifungal Drug Transport: Characterizing the Role of Membrane Transporters in Pathogenic Fungi
(2016)Pathogenic fungi cause serious disease and even death in humans, animals and plants. In medicine and agriculture alike, fungal infections are widespread and represent a significant threat to global public health. The ... -
The Molecular Mechanisms of Antifungal Drug Resistance In Pathogenic Fungi
(2016)Pathogenic fungi including Candida albicans, cause oral, systemic, and vaginal infections, mostly in immune-compromised individuals. Azoles are the most common antifungals used in treating these infections. The most ... -
Expression Pattern of Drug-Resistance Genes in Matched Clinical Isolates of Candida albicans at Variable Fluconazole Exposure Times
(2016)Candida albicans is an opportunistic fungus that exists naturally in the vaginal, urinary, and gastrointestinal tracts of humans. Typically, this yeast remains balanced with the body’s other natural microbial flora and the ... -
Alterations in cardiac contractility and heart rate mediated by bone loading
(2022)The skeleton is a dynamic organ in complex interplay with the other systems of the body and is highly responsive to input from the external environment. Increasingly, evidence is mounting that the skeleton is the source ... -
Effects of Light on BDBT Puncta Formation in the Drosophila Eye Reveal Involvement of BDBT with Color Preference Behavior and Distinct Nuclear Localization Pathways for DBT and PER
(2021)In this dissertation, the research focus is on elucidating the mechanism behind BRIDE OF DOUBLETIME (BDBT) puncta/foci formation. During this process it was discovered that both the circadian and visual photoreceptors ... -
The canonical Wnt signaling pathway affects regeneration of mechanosensory hair cells in Danio Rerio
(2020)In vertebrates, mechanosensory hair cells are located in the inner ear and mediate hearing. When damage to these specialized cells occur, it leads to irreversible hearing loss. Not only do aquatic vertebrates have inner ... -
APP∙CNTN Complex Architecture is Conserved Throughout the Vertebrate Lineage
(2020)Contactins (CNTNs) are a group of up to six cell adhesion molecules (CAMs) of the immunoglobulin (Ig) superfamily found throughout the metazoan lineage. CNTN architecture is broadly conserved, and these proteins are composed ... -
Investigation of functional domains of drosophilia tribbles protein in the insulin signaling pathway
(2020)In this dissertation, I examined the function of the Drosophila melanogaster protein Tribbles (Trbl) within the insulin/insulin-like signaling (IIS) pathway. Trbl was initially discovered as a regulator of mitosis during ... -
Structure-Function Analysis of the Tribbles Pseudokinase
(2020)Members of the Tribbles (Trb) family of pseudokinases have roles in development, cell cycle control, insulin signaling, and the immune response and have been linked to many human diseases. The structure of Drosophila ... -
Non-genomic control of neuronal calcium signaling by the steroid hormone estrogen leads to neuroprotective effects
(2020)It has been well documented that the onset of menopause correlates with an increase in the onset of neurodegenerative diseases such as Alzheimer’s disease. Estrogen supplementation was used as treatment/prevention for a ... -
Mechanism of Action of Nicotinamide Phosphoribosyltransferase Mediated Signaling in Oxidative Stress
(University of Missouri -- Kansas City, 2018)Worldwide there are an estimated 1 billion people that are affected by a form of neurodegenerative disease. The most common forms of neurodegenerative disease are Alzheimer’s disease and Parkinson’s disease, along ... -
Structure/Function Analysis of Type IIa Receptor Tyrosine Phosphatases on Drosophila Muscle Integrity
(University of Missouri -- Kansas City, 2018)The Lar-family of receptor protein tyrosine phosphatases (RPTPs); including Lar, RPTPσ and RPTPδ, are utilized in signal transduction pathways during neural development. Fundamentally, the processes of axon guidance ... -
Identification of Novel Regulatory Genes in Acetaminophen Induced Hepatocyte Toxicity by a Genome-Wide CRISPR/Cas9 Screen
(University of Missouri -- Kansas City, 2018)Acetaminophen (APAP) is a commonly used analgesic responsible for over 56,000 overdose-related emergency room visits annually. A long asymptomatic period and limited treatment options result in a high rate of liver ... -
A Genetic Screen for Tribbles Suppressors Identifies the E3 Ubiquitin Ligase Neuralized as a Novel Target
(University of Missouri -- Kansas City, 2017)In this dissertation, I used the Drosophila wing as a model tissue for a genetic screen to identify novel targets of Tribbles. Drosophila Tribbles is the founding member of a family of pseudokinases conserved between ...