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Epigenetic Regulation Of The HIF Pathway And Novel Therapeutic Opportunities
(2014-08-28)
The research presented in this dissertation is aimed at understanding the epigenetic
regulation of the HIF pathway and the efficacy of treatment for retinal diseases and
hemangioblastomas using HIF pathway inhibitors. ...
Mating Type Specific Roles During The Sexual Cycle Of Phycomyces Blakesleeanus
(2014)
Phycomyces blakesleeanus is a filamentous fungus that belongs in the order Mucorales. It can propagate through both sexual and asexual reproduction. The asexual structures of Phycomyces called sporangiophores have served ...
The Role of Host Translation Initiation Factors eIF4H and eIF4A and the Exon Junction Complex in the Control of mRNA turnover and Translation by the Virion Host Shut off Protein of Herpes Simplex Virus
(2013)
During lytic infections, the HSV Vhs endonuclease (UL41) degrades many viral and cellular mRNAs. This endonuclease activity is dependent upon the ability of Vhs to bind the host translation initiation factors eIF4AI/II and ...
Disconnecting a Role for DNA Repair in the Pathogenicity of the Human pathogen Cryptococcus neoformans
(2014)
C. neoformans is an opportunistic fungal pathogen causing fatal meningitis and lung infections. Worldwide every year around 625,000 deaths occur due to Cryptococcosis. A basic understanding of Cryptococcus virulence ...
The Cellular and Molecular Mechanisms of Prostaglandin E₂ in Myogenesis
(2013)
Prostaglandin E₂ (PGE₂), the most abundant prostaglandin (PG) in our body, has multiple biological functions related to physiological activities and the development of diseases. Emerging evidence has shown that PGE2 plays ...
Regulation of Gene Expression by Non-coding RNAs in Arabidopsis and Brachypodium
(2014)
Expansion of high-throughput sequencing technology has increased our understanding
in the importance of pervasive transcription and the resulting indispensable molecules, noncoding
RNAs (ncRNAs). A significant effort has ...
Independent Functions Of Clueless In Differential Integrin Secretion And Mitochondrial Quality Control In Drosophila Muscle
(2015)
Drosophila Clueless (Clu) and its conserved orthologs are known for their role in the prevention of mitochondrial clustering. Here, we uncover its independent roles in the delivery of integrin subunits and the regulation ...
The function of Drosophila Integrin-Dim7-Elmo-Mbc→Rac signaling pathway in the muscle attachment formation and maintenance
(2013)
The Engulfment and Cell Motility (Elmo)-(Myoblast city) Mbc→Rac signaling pathway is evolutionarily conserved from C. elegans to vertebrates and is essential for many developmental processes, including phagocytosis and ...
The Middle Region is Required for Phosphorylation Regulation of Ceramide Transfer Protein
(2013)
The trafficking of ceramide from endoplasmic reticulum (ER), where it is synthesized, to the Golgi for sphingomyelin synthesis is mediated by the ceramide transfer protein (CERT) in a nonvesicular fashion. CERT is a cytosolic ...
Discovery of Enzymes Responsible for an Alternate Mevalonate Pathway in Haloferax volcanii
(2014-09-30)
Archaea are a distinct evolutionary domain of microorganisms that contain isoprenoids in ether linkages to glycerol rather than the ester linked fatty acids that characterize membranes of bacteria or eukaryotes. Radiolabeling ...
Toxicty of a Serotonin-derived Neuromelanin
(2010)
Introduction: POCD (Postoperative Cognitive Dysfunction) is associated with increased mortality and disability and may develop as a consequence of lipid peroxidative byproducts (i.e. acrolein), which accumulate with aging. ...
3-Hydroxy-3-methylglutaryl-coenzyme A lyase: investigation of cysteines mediating intersubunit disulfide formation and regulation by thiol/disulfide exchange and discovery of an extramitochondrial homolog
(University of Missouri -- Kansas City, 2012-01-18)
3-Hydroxy-3-methylglutaryl-Coenzyme A lyase catalyzes the cleavage of 3-hydroxy-
3-methylglutaryl-Coenzyme A into acetoacetate and acetyl-Coenzyme A, a key reaction
in ketogenesis and leucine catabolism. Previous work ...
The herpes simplex virus virion host shutoff protein is targeted to mRNA cleavage sites through interactions with components of the host translational apparatus
(University of Missouri--Kansas City, 2011-01-20)
The virion host shutoff protein (Vhs) is a herpes simplex virus (HSV) protein involved in early shutoff of the host cell. It is a component of the infecting virion, located in the tegument region, that works by rapidly ...
Mutational and functional analyses of the dynein heavy chain indicate the existence of an apical-sistal transport cycle in cells
(University of Missouri--Kansas City, 2012-03-02)
The organization, survival, and function of eukaryotic cells depend on intracellular
transport governed by the microtubule based molecular motors cytoplasmic dynein and
kinesin. Dynein carries out the inward transport ...
Structural and functional studies of type three secretion virulence factors from gram-negative pathogenic bacteria
(University of Missouri-Kansas City, 2011-12-21)
Many pathogenic Gram-negative bacteria utilize type III secretion systems (TTSS) to alter the normal functions of target host epithelial cells. Of the 1.1 million deaths that are caused by Shigella each year, nearly a third ...
The expression and regulation on antimicrobial peptide genes in insects: studies in the tobacco hornworm manduca sexta
(University of Missouri--Kansas City, 2011-05-10)
Insects have evolved an efficient innate immune system to combat microbes. Most of our knowledge of insect immunity comes from studies with dipteran and lepidopteran insects, such as the fruit fly Drosophila melanogaster, ...
A proteomic approach for studying LTR retrotransposon host factors in saccharomyces cerevisae
(University of Missouri--Kansas City, 2012-01-20)
The Ty retrotransposons of S. cerevisiae are mobile elements that resemble retroviruses, both in their genetic structures and replication cycles. Ty retrotransposition begins in the nucleus with the transcription of Ty ...
Functional Sorting of Evolutionary Effects in Protein Domains
(University of Missouri--Kansas City, 2010)
One of the most important questions in evolutionary genetics is whether a gene of interest is under positive selection, negative selection or neutral evolution. Although there are numerous existed methods and statistical ...
Novel in vitro cell culture models for studying pharmacokinetic drug-drug interactions following oral administration
(University of Missouri--Kansas City, 2011-09-21)
In this study different in vitro models were developed to study the long term and short term drug- drug interactions occurring upon oral administration. MDCK cells were stably transfected for the simultaneous expression ...
Involvement of a specific ubiquitin ligase in the assembly of the dynein motor in the filamentous fungus Neurospora crassa
(University of Missouri--Kansas City, 2012-08-27)
Eukaryotic cells utilize multiple molecular motor proteins to accomplish
intracellular transport. The two microtubule based motors, kinesin and cytoplasmic
dynein, work in concert to move cargoes outward and inward, ...