Browsing College of Engineering (MU) by Thesis Advisor "Lee, James C."
Now showing items 1-7 of 7
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Amyloid- [beta] peptide induces temporal membrane biphasic changes in astrocytes through cytosolic phospholipase A₂
(University of Missouri--Columbia, 2010)Oligomeric amyloid-[beta] peptide (A[beta]) is known to induce cytotoxic effects and damage cell functions in Alzheimer's disease. However, mechanisms underlying the effects of A[beta] on cell membranes have yet to be fully ... -
Azelnidipine attenuates inflammatory responses, siperoxide and relevant signaling pathways induced by amyloid-beta in mouse cerebral endothelial cells
(University of Missouri--Columbia, 2014)Alzheimer's disease (AD) is a debilitating neurodegenerative disease with no known cure. The cause and progression of AD is still unclear. Over the years, studies have shown that one of the earliest cytotoxic effects is ... -
CPLA2: key enzyme for astroctytic cell membrane phase property change induced by abeta
(University of Missouri--Columbia, 2007)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] The interaction of amyloid beta peptide (A[beta]) and cell membrane is believed to be the basis of its biological function including its toxicity to ... -
H₂O₂-mediated RAGE up-regulation on A[beta]-induced superoxide in cerebral endothelial cells
(University of Missouri--Columbia, 2013)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] The up-regulation of receptor for advanced glycation (RAGE) product has been implicated in the pathophysiology of Alzheimer's disease (AD). Elevated ... -
Photo-biomodulation and soybean isoflavones on amyloid-beta peptide-induced oxidative stress and inflammation
(University of Missouri--Columbia, 2013)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Alzheimer's disease (AD) is a chronic neurodegenerative disorder, and the aggregation of amyloid-[beta]-peptide (A[beta]) is recognized as one of the ... -
The role of phospholipase A2 in amyloid [beta] uptake by microglia
(University of Missouri--Columbia, 2015)The accumulation of amyloid-beta (Abeta) is a key characteristic of Alzheimer's disease (AD). Microglia are the principle macrophages in the brain and are known to internalize Abeta, however the phagocytic function is ... -
Tnf[alpha] alters occludin and endothelial cell barrier function : role of p38MAPK
(University of Missouri--Columbia, 2016)Occludin is one of the key tight junction (TJ) proteins in endothelial cells and it plays an important role in modulating blood brain barrier (BBB) function. This protein (65kDa) has been shown to engage in many signaling ...