RSS 1.0School of Pharmacy (UMKC)
The UMKC School of Pharmacy will be an internationally respected learning community which creates standards in practice, education and research to promote health and quality of life.
The School of Pharmacy's mission is to educate students, health care professionals and scientists, conduct research, and serve the public and the pharmacy profession in order to meet pharmaceutical needs and advance the standard of health care.
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Recent Submissions
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Effect of TIMBD on Neurotoxicity Associated with HIV-1 Gp120 and Tat
(University of Missouri -- Kansas City, 2018)Human Immunodeficiency Virus (HIV)-associated neurocognitive disorder (HAND) is one of the undermining disorders that affects majority of HIV infected patients. Patients with HAND suffer from both cognitive and motor ... -
Long Term Ocular Drug Delivery with Novel Pentablock Copolymers; Part I: Composite Nanoformulation of Macromolecules For Back of the Eye Diseases, Part II: Dexamethasone Nanoparticle to Develop an In Vitro Model for Glaucoma
(University of Missouri -- Kansas City, 2017)Pentablock (PB) copolymers have been successfully synthesized for long term delivery in the treatment of posterior segment ocular diseases. PB copolymers are comprised of FDA approved biodegradable polymer such as ... -
The effects of HIV-1 viral protein r (vpr) and anti-retroviral drugs in the brain: Implications in HIV-1 associated neurocognitive disorders
(University of Missouri--Kansas City, 2016)The morbidity and mortality of HIV-1 infected individuals has declined significantly by the introduction of highly active antiretroviral therapy (HAART). Nevertheless, different forms of HIV-1 associated neurocognitive ... -
Discovery of Peptide and Aptamer Ligands for Targeted Drug Delivery to Hepatic Stellate Cells
(University of Missouri--Kansas City, 2016)The objective of this dissertation is to present two approaches to identify Hepatic Stellate Cells (HSCs) targeting ligands using phage-display library biopanning and systematic evolution of ligands by exponential ... -
Metabolomic Analysis of Bacterial Cell Wall Intermediates Using LC-MS/MS: Peptidoglycan Pathway Response to Different Antibiotics
(University of Missouri--Kansas City, 2017)The bacterial cell wall is made up of peptidoglycan (PG) and its synthesis is of interest as a target for several antibiotics and for new inhibitor development. Peptidoglycan biosynthesis is a complex process which ... -
Synthesis, Characterization and Device Studies of Conjugated Foldamers
(University of Missouri--Kansas City, 2017)Conjugated polymers have found a wide range of electronic applications in last few decades due to their superior combination of optoelectronic, mechanical properties, and solution processability. In the past few years, ... -
Novel Approaches for Targeted Delivery of Cancer Therapeutics to Nuclei of Malignant Cells
(University of Missouri--Kansas City, 2016)The primary goal of this project is to increase specific uptake of anti-cancer therapeutics by nuclei of cancer cells. A lot of research has been done to target therapeutics specifically across plasma membrane of ... -
Formulation of Hyaluronidase Enzyme Sensitive Topical Nanomicrobicides for HIV Virus Transmission Prevention
(University of Missouri--Kansas City, 2016)The objective of this dissertation is to design and optimize a nanoformulations (nanoparticle and nanofiber) delivery system loaded with anti-HIV topical microbicides for HIV prevention in women. In chapters 1 and ... -
Development and Evaluation of Nanocarriers against Atherosclerosis
(University of Missouri--Kansas City, 2016)The objective of this project was to develop advanced nanocarriers such as nanographene and graphene quantum dots against atherosclerosis. Mannosylated-reduced graphene oxide (Man-rGO) was developed as a targeted ... -
Role of Toll-Like Receptor 4 in Oxidant-induced Inflammatory Phenotypes in Macrophages
(University of Missouri--Kansas City, 2017)A common mechanism by which redox stress may activate inflammatory responses to potentially initiate, propagate and maintain many diseases states has not been characterized. Accumulating evidence suggests that pattern ... -
The effect of HIV-1 Tat and methamphetamine on expression of cytokines/chemokines and synaptic genes: Implications in HIV neuroAIDS
(University of Missouri--Kansas City, 2017)Human immunodeficiency virus-1 (HIV-1) enters the brain through blood brain barrier (BBB) early after the infection and leads to various neurological complications including HIV associated dementia (HAD). Introduction ... -
The Effect of Drugs of Abuse and HIV-1 GP120 on Autophagy in Astrocytes
(University of Missouri--Kansas City, 2016)The life expectancy of individuals infected with HIV-1 has significantly improved since the introduction of highly active anti-retroviral therapy (HAART). However, this has led to an increase in the prevalence of HIV-associated ... -
Refinement and Applications of Light Controlled Biological Processes
(University of Missouri–Kansas City, 2015)For understanding of biological processes, a spatiotemporal control over these processes is needed. Controlling these processes using light can give us the advantage of a precise control over spacing, timing and degree of ... -
Topical Clear Aqueous Nanomicellar Formulation for Anterior and Posterior Ocular Drug Delivery
(University of Missouri–Kansas City, 2015)The objective of this study was to develop a clear, aqueous drug loaded nanomicellar formulation (NMF) for the back-of-the-eye delivery. Hydrophobic drugs such as cyclosporine, resolvin analog (RX-10045), dexamethasone, ... -
Development of Advanced Delivery Systems for Microbicides
(2016)HIV/AIDS still continues to be a pandemic and global emergency and is a leading cause of death among the women of reproductive age (15-49 yr). Women are more vulnerable for HIV infection due to anatomical and physiological ... -
Cytochrome P450 enzymes and oxidative stress in tobacco/nicotine mediated HIV pathogenesis
(2016)In the US, the prevalence of cigarette smoking in the HIV-infected population is 50-70% compared to 15-20% in the general population, which further increases the risk of smoking-related health problems in this group. ... -
The Study of Initiation Systems and Formulations for the Development of a Novel Silorane Biomaterial
(2015)There are approximately one million hip and knee replacements each year in the United States alone and over 70% are cemented for stabilization. The number of these replacements is expected to rise to 3.5 million per year ... -
Design and Evaluation of HIV Microbicides Loaded mucoadhesive Nanoformulation
(2015)HIV/AIDS had caused more than 25 million deaths since it was first recognized. Women are more susceptible to HIV infection in comparison with men due to human physiology, social, economic disadvantages. To protect women ... -
Studies of Conjugated Small Molecules, Polymers and Organic-Inorganic Hybrid Materials for Photovoltaic Applications
(2015)This dissertation focuses on the photophysical properties and device studies of three different types of materials, namely polyoxometalate (POM)-containing organic-inorganic hybrids, near-IR absorbing conjugated polymers ... -
Recent Advances in Indole Aryne Cycloaddition Chemistry. Part I: Total Synthesis of (±)-cis-Trikentrin B. Part II: Investigation into the Regioselectivity of 6,7-Indole Aryne Cycloadditions. Part III: Synthesis and Reactions of Novel Tribromoindoles
(2015)Since their discovery in the Buszek laboratories in 2007, the indole arynes and their cycloaddition chemistry has demonstrated its significance in achieving the total synthesis of biologically active indole alkaloid natural ...