RSS 1.0School of Pharmacy (UMKC)
The UMKC School of Pharmacy will be an internationally respected learning community which creates standards in practice, education and research to promote health and quality of life.
The School of Pharmacy's mission is to educate students, health care professionals and scientists, conduct research, and serve the public and the pharmacy profession in order to meet pharmaceutical needs and advance the standard of health care.
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Recent Submissions
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Synthesis, Characterization and Device Studies of Conjugated Foldamers
(University of Missouri--Kansas City, 2017)Conjugated polymers have found a wide range of electronic applications in last few decades due to their superior combination of optoelectronic, mechanical properties, and solution processability. In the past few years, ... -
Novel Approaches for Targeted Delivery of Cancer Therapeutics to Nuclei of Malignant Cells
(University of Missouri--Kansas City, 2016)The primary goal of this project is to increase specific uptake of anti-cancer therapeutics by nuclei of cancer cells. A lot of research has been done to target therapeutics specifically across plasma membrane of ... -
Formulation of Hyaluronidase Enzyme Sensitive Topical Nanomicrobicides for HIV Virus Transmission Prevention
(University of Missouri--Kansas City, 2016)The objective of this dissertation is to design and optimize a nanoformulations (nanoparticle and nanofiber) delivery system loaded with anti-HIV topical microbicides for HIV prevention in women. In chapters 1 and ... -
Development and Evaluation of Nanocarriers against Atherosclerosis
(University of Missouri--Kansas City, 2016)The objective of this project was to develop advanced nanocarriers such as nanographene and graphene quantum dots against atherosclerosis. Mannosylated-reduced graphene oxide (Man-rGO) was developed as a targeted ... -
Role of Toll-Like Receptor 4 in Oxidant-induced Inflammatory Phenotypes in Macrophages
(University of Missouri--Kansas City, 2017)A common mechanism by which redox stress may activate inflammatory responses to potentially initiate, propagate and maintain many diseases states has not been characterized. Accumulating evidence suggests that pattern ... -
The effect of HIV-1 Tat and methamphetamine on expression of cytokines/chemokines and synaptic genes: Implications in HIV neuroAIDS
(University of Missouri--Kansas City, 2017)Human immunodeficiency virus-1 (HIV-1) enters the brain through blood brain barrier (BBB) early after the infection and leads to various neurological complications including HIV associated dementia (HAD). Introduction ... -
The Effect of Drugs of Abuse and HIV-1 GP120 on Autophagy in Astrocytes
(University of Missouri--Kansas City, 2016)The life expectancy of individuals infected with HIV-1 has significantly improved since the introduction of highly active anti-retroviral therapy (HAART). However, this has led to an increase in the prevalence of HIV-associated ... -
Refinement and Applications of Light Controlled Biological Processes
(University of Missouri–Kansas City, 2015)For understanding of biological processes, a spatiotemporal control over these processes is needed. Controlling these processes using light can give us the advantage of a precise control over spacing, timing and degree of ... -
Topical Clear Aqueous Nanomicellar Formulation for Anterior and Posterior Ocular Drug Delivery
(University of Missouri–Kansas City, 2015)The objective of this study was to develop a clear, aqueous drug loaded nanomicellar formulation (NMF) for the back-of-the-eye delivery. Hydrophobic drugs such as cyclosporine, resolvin analog (RX-10045), dexamethasone, ... -
Development of Advanced Delivery Systems for Microbicides
(2016)HIV/AIDS still continues to be a pandemic and global emergency and is a leading cause of death among the women of reproductive age (15-49 yr). Women are more vulnerable for HIV infection due to anatomical and physiological ... -
Cytochrome P450 enzymes and oxidative stress in tobacco/nicotine mediated HIV pathogenesis
(2016)In the US, the prevalence of cigarette smoking in the HIV-infected population is 50-70% compared to 15-20% in the general population, which further increases the risk of smoking-related health problems in this group. ... -
The Study of Initiation Systems and Formulations for the Development of a Novel Silorane Biomaterial
(2015)There are approximately one million hip and knee replacements each year in the United States alone and over 70% are cemented for stabilization. The number of these replacements is expected to rise to 3.5 million per year ... -
Design and Evaluation of HIV Microbicides Loaded mucoadhesive Nanoformulation
(2015)HIV/AIDS had caused more than 25 million deaths since it was first recognized. Women are more susceptible to HIV infection in comparison with men due to human physiology, social, economic disadvantages. To protect women ... -
Studies of Conjugated Small Molecules, Polymers and Organic-Inorganic Hybrid Materials for Photovoltaic Applications
(2015)This dissertation focuses on the photophysical properties and device studies of three different types of materials, namely polyoxometalate (POM)-containing organic-inorganic hybrids, near-IR absorbing conjugated polymers ... -
Recent Advances in Indole Aryne Cycloaddition Chemistry. Part I: Total Synthesis of (±)-cis-Trikentrin B. Part II: Investigation into the Regioselectivity of 6,7-Indole Aryne Cycloadditions. Part III: Synthesis and Reactions of Novel Tribromoindoles
(2015)Since their discovery in the Buszek laboratories in 2007, the indole arynes and their cycloaddition chemistry has demonstrated its significance in achieving the total synthesis of biologically active indole alkaloid natural ... -
Evaluation of therapeutic effect of PCBP2 siRNA on hepatic stellate cells and development of a streptavidin-based siRNA delivery system
(2014)Type I collagen accumulates during liver fibrosis primarily because α-complex protein-2 (αCP2), encoded by the poly(rC) binding protein 2 (PCBP2) gene, binds to the 3′end of the collagen mRNA and increases its half-life. ... -
Development of polymeric nanoparticulate formulation encapsulating protein molecules following hydrophobic ion pairing complexation
(2014)Several formulation strategies have been employed to enable sustained delivery of antibody therapeutics by nanoparticulate based dosage forms. However, development of sustained release nanoparticulate based dosage form for ... -
Development of Pentablock Copolymer Based Formulations for the Sustained Delivery of Protein Therapeutics in the Treatment of Posterior Segment Ocular Diseases
(2013)We have successfully synthesized pentablock (PB) copolymers comprised of various FDA approved polymer blocks such as polyethylene glycol (PEG), polycaprolactone (PCL), polylactic acid (PLA) and polyglycolic acid (PGA). PB ... -
The Cellular and Molecular Mechanisms of Prostaglandin E₂ in Myogenesis
(2013)Prostaglandin E₂ (PGE₂), the most abundant prostaglandin (PG) in our body, has multiple biological functions related to physiological activities and the development of diseases. Emerging evidence has shown that PGE2 plays ... -
Novel Transporter Targeted Lipid Ester Prodrugs of Cidofovir and Sustained Release Formulations for Cytomegalovirus Infection
(2013)Cidofovir (CDF) has shown potential in vitro and in vivo antiviral activity against cytomegalovirus (CMV) retinitis. However, low CDF permeability due to its hydrophilic nature limits its effectiveness. Furthermore, ...