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The UMKC School of Pharmacy will be an internationally respected learning community which creates standards in practice, education and research to promote health and quality of life.
The School of Pharmacy's mission is to educate students, health care professionals and scientists, conduct research, and serve the public and the pharmacy profession in order to meet pharmaceutical needs and advance the standard of health care.
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Recent Submissions
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Nanomicelles And Liposomes For Improving Drug Delivery of Small Molecules And siRNA Therapeutic Agents
(2021)PART I: SELF-ASSEMBLING TACROLIMUS NANOMICELLES FOR BACK OF THE EYE DISEASES Vrinda Gote, Candidate for the Doctor of Philosophy Degree University of Missouri-Kansas City, 2021 ABSTRACT Neovascular age-related ... -
Development of Targeted siRNA Therapeutics for Triple Negative Breast Cancer and Liver Fibrosis
(University of Missouri -- Kansas City, 2018)The objective of this dissertation is to develop various systems to deliver small interfering RNA (siRNA) for the treatment of triple negative breast cancer (TNBC) and liver fibrosis. siRNAs targeting vascular endothelial ... -
Evaluation of the Anti-Fibrotic Activity of PCBP2 siRNA in Primary Hepatic Stellate Cells and Discovery of Anti-PD-L1 Peptide and Nanobody for Immunotherapy
(University of Missouri -- Kansas City, 2018)There are two major research objectives in this dissertation. Our laboratory recently discovered a small interfering RNA (siRNA) that silences the poly (rC) binding protein 2 (PCBP2) gene. It is hypothesized that silencing ... -
Establishing Metronidazole as a Novel Biomarker of CYP2A6 Activity
(University of Missouri -- Kansas City, 2018)CYP2A6 is a polymorphically expressed enzyme with variation associated with smoking behavior, cessation success, lung cancer risk, and differential drug exposure to numerous medications including anti-infectious and ... -
Metabolomics and chemical library screening for antibacterial drug discovery
(2020)There are twenty standard amino acids which are proteinogenic and can exist in two stereoisomeric forms, D- and L-enantiomers, except for glycine, which is achiral. The D-amino acids are not incorporated in proteins; ... -
Topical Clear Aqueous Nanomicellar Formulations for Age-Related Macular Degeneration
(2020)Disorders affecting the posterior segment of eyes represent a significant burden to healthcare and patients’ wellbeing. Among the back of the eye disorders, age-related macular degeneration (AMD) is one of the major ailments ... -
Synthesis, Characterization and In-vivo Testing of Photoactivatable Insulin Depots for Continuously Variable and Minimally Invasive Insulin Delivery
(University of Missouri -- Kansas City, 2019)Proteins are macromolecules involved in a diverse array of functions. Mutations or abnormal levels of proteins are indicated in several diseases. Despite showing early promise, the translation of protein therapeutics ... -
Part I: Synthesis of functionalized bile acids towards the construction of steroidal macrocycles. Part II: Evaluation and expansion of a modular card game for teaching organic chemistry
(2019)In Part I, the synthesis of chenodeoxychoic acid (CDCA) derivatives towards the construction of unique chemical architectures are reported. Building on previously described methods, CDCA based macrocycles with inner cavities ... -
The Investigation of Configurationally Stable Longitudinally Twisted Acenes and the Development of a Silorane-Based Biomaterial for Use as an Antimicrobial Delivery Device
(2019)Longitudinally twisted acenes (LTAs) adopt a helical twist in order to alleviate steric congestion caused by bulky substituents along the acene backbone and are inherently chiral. As is observed in helicenes, this helical ... -
Role of Redox-Active Trace Metal (RATM) Oxidants in the Regulation of Toll-Like Receptor 4 (TLR4) Signaling-Mediated Inflammatory Phenotype in Synovial Fibroblasts
(University of Missouri -- Kansas City, 2018)While the involvement of oxidant stress in rheumatoid arthritis (RA) has been suspected, the role of redox-active trace metals (RATM) as exogenous pro-oxidants in the pathogenesis of RA has not yet been investigated. ... -
Development of Protein Based PCBP2 siRNA Nanocomplex for Liver Fibrosis Therapy
(University of Missouri -- Kansas City, 2018)The objective of this dissertation is to develop a protein-based siRNA nanocomplex for the treatment of alcoholic liver fibrosis. Our laboratory recently discovered that silencing the poly (rC) binding protein 2 (PCBP2) ... -
Estrogen Regulation of the Wnt/β-catenin Pathway in Osteocytes in Response to Mechanical Loading
Osteoporosis is a major health concern, especially for women who are peri- and post-menopausal. During this time, estrogen levels dramatically decline followed by a subsequent loss of bone density, which increases risk of ... -
Novel Dichloroacetate Prodrugs for Improved Targeting of Breast Cancer Chemotherapeutics
(University of Missouri -- Kansas City, 2019)It is well documented that most cancer cells utilize aerobic glycolysis or Warburg metabolism instead of mitochondrial oxidative phosphorylation for cell energy production. Dichloroacetate is a synthetic small molecule ... -
Engineering of Human Acid Phosphatase Enzyme Sensitive Nanomedicine for HIV/AIDS Prevention by Topical Route
(University of Missouri -- Kansas City, 2018)This study is divided into two aims. Aim #1 focuses on the development and characterization of tenofovir (TFV) loaded a stimuli sensitive nanomedicine against male to female HIV/AIDS infection. Aim #2 focus on the ... -
Novel Folic Acid Targeted Nanomicelles For Delivery Of Hydrophobic Drugs To The Back Of The Eye
(University of Missouri -- Kansas City, 2019)Overall aim of this research project is to develop folic acid targeted nanomicelles loaded with insoluble hydrophobic drugs for delivery to posterior segment of the eye. Retinoblastoma and uveitis are diseases that ... -
Development of Random Triblock Copolymer Based Nanoparticulate Formulation for Sustained Release of Macromolecules/Biologics in Treatment of Posterior Segment Ocular Diseases
(University of Missouri -- Kansas City, 2018)Random triblock copolymers (RTB) were successfully synthesized by ring opening copolymerization method. RTB copolymers are composed of FDA approved materials such as polyethylene glycol (PEG), glycolide (GA), lactide ... -
Novel Prodrugs and Self-Assembling Nanocarriers to Improve Drug Delivery
(University of Missouri -- Kansas City, 2018)PART I: DIPEPTIDE PRODRUG APPROACH TO IMPROVE INTESTINAL ABSORPTION OF LOPINAVIR Lopinavir (LPV), a highly potent second-generation HIV-1 protease inhibitor, is currently indicated in HIV-1 infection. However, poor ... -
Discovery of PSMA-Specific Peptide Ligands and Development of A Noncovalent Method to Attach Chemical Moieties to siRNA
(University of Missouri -- Kansas City, 2017)The objective of this dissertation is to discover PSMA (Prostate Specific Membrane Antigen)-specific peptide ligands using phage display and employ peptide nucleic acid as a complementary linker to attach chemical ... -
Clear, Aqueous Topical Nanomicelle Formulation For Diabetic Macula Edema
(University of Missouri -- Kansas City, 2018)The objective of this study was to develop a clear aqueous mixed nanomicellar formulation (NMF) of hydrophobic drugs for diabetic macula edema. The hydrophobic drugs include triamcinolone acetonide (TA), fluocinolonce ... -
Preparation of Pentablock Nanomicellar Formulations for Prostate Cancer Drug Delivery Systems
(University of Missouri -- Kansas City, 2018)This study is divided into three specific aims. Specific aim #1 focused on synthesis of pentablock co-polymer using monomers of L-lactide, ε-caprolactone and ethylene-glycol with varied molecular weights, (ii) ...