Browsing School of Pharmacy (UMKC) by Thesis Department "Pharmacology (UMKC)"
Now showing items 1-19 of 19
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Alcohol/HIV-Induced Neurodeficit and Circumvention by Neuroprotective Agent
(2023)Alcohol Use Disorder (AUD) remains a major problem in the United States, with usage varying between acute (binge) and chronic (heavy usage) staging. Alcohol Use Disorders affect 14.5 million people, with 9 million men and ... -
Characterization of D-boroala as a novel Broad-spectrum antibacterial agent targeting D-Ala-D-Ala ligase & designer linkers : model reactions and linear free energy relationships in the reactivity and design of solid-phase linkers
(2014-07-18)Bacterial infections were the major cause of death and morbidity prior to the development of modern antibiotics, and the increasing resistance of pathogenic bacteria to commonly used antibacterial agents is a major public ... -
Characterization of the Organic Matrix of Mature Human Tooth Enamel: Structure, Macromolecular Composition and Effect of Radiotherapy
(2014-09-30)Mature human tooth enamel contains a small amount of organic matrix locally concentrated within its innermost region, which is tougher and more crack resistant than the outer bulk phase. Although the enamel organic matrix ... -
Cytochrome P450 enzymes and oxidative stress in tobacco/nicotine mediated HIV pathogenesis
(2016)In the US, the prevalence of cigarette smoking in the HIV-infected population is 50-70% compared to 15-20% in the general population, which further increases the risk of smoking-related health problems in this group. ... -
The effect of HIV-1 Tat and methamphetamine on expression of cytokines/chemokines and synaptic genes: Implications in HIV neuroAIDS
(University of Missouri--Kansas City, 2017)Human immunodeficiency virus-1 (HIV-1) enters the brain through blood brain barrier (BBB) early after the infection and leads to various neurological complications including HIV associated dementia (HAD). Introduction ... -
Effect of TIMBD on Neurotoxicity Associated with HIV-1 Gp120 and Tat
(University of Missouri -- Kansas City, 2018)Human Immunodeficiency Virus (HIV)-associated neurocognitive disorder (HAND) is one of the undermining disorders that affects majority of HIV infected patients. Patients with HAND suffer from both cognitive and motor ... -
Effects of Flavonoids on Collagen Biostability, Remineralization and Long Term Durability of Natural and Denatured Dentin
(2022)Collagen biostability in the resin dentin interface determines the longevity of dental composite restorations. Maintaining this biostability becomes even more challenging in the altered and denatured substrate of caries ... -
The effects of HIV-1 viral protein r (vpr) and anti-retroviral drugs in the brain: Implications in HIV-1 associated neurocognitive disorders
(University of Missouri--Kansas City, 2016)The morbidity and mortality of HIV-1 infected individuals has declined significantly by the introduction of highly active antiretroviral therapy (HAART). Nevertheless, different forms of HIV-1 associated neurocognitive ... -
Establishing Metronidazole as a Novel Biomarker of CYP2A6 Activity
(University of Missouri -- Kansas City, 2018)CYP2A6 is a polymorphically expressed enzyme with variation associated with smoking behavior, cessation success, lung cancer risk, and differential drug exposure to numerous medications including anti-infectious and ... -
Estrogen Regulation of the Wnt/β-catenin Pathway in Osteocytes in Response to Mechanical Loading
Osteoporosis is a major health concern, especially for women who are peri- and post-menopausal. During this time, estrogen levels dramatically decline followed by a subsequent loss of bone density, which increases risk of ... -
HIV-1 gp120 and Methamphetamine-mediated Induction of Proinflammatory Cytokines/chemokines and Oxidative Stress in Astrocytes: Implications in Neuroinflammation
(2014-04-02)HIV associated neurocognitive disorder (HAND) remains a major concern for patients infected with HIV. The viral envelope protein, gp120 has been extensively studied and some of its neurotoxic effects are due to the increased ... -
Nanomicelles And Liposomes For Improving Drug Delivery of Small Molecules And siRNA Therapeutic Agents
(2021)PART I: SELF-ASSEMBLING TACROLIMUS NANOMICELLES FOR BACK OF THE EYE DISEASES Vrinda Gote, Candidate for the Doctor of Philosophy Degree University of Missouri-Kansas City, 2021 ABSTRACT Neovascular age-related ... -
Potential Mechanisms for Inhibition of Breast Cancer by Novel Azaresveratrol Analogs: Implications of Estrogen Receptor, Estrogen Metabolism and Cell Death Pathways
(2015-06-19)Prolonged exposure to estrogens has been implicated in the development of breast cancers. Steroidal estrogens have been implicated in the initiation and progression of cancer. Estrogens bind to their cognate estrogen ... -
Preparation of Pentablock Nanomicellar Formulations for Prostate Cancer Drug Delivery Systems
(University of Missouri -- Kansas City, 2018)This study is divided into three specific aims. Specific aim #1 focused on synthesis of pentablock co-polymer using monomers of L-lactide, ε-caprolactone and ethylene-glycol with varied molecular weights, (ii) ... -
Proinflammatory Cytokine / Chemokine Expression in Human Astrocytes: Induction by HIV-1 Nef
(2014)The mortality and morbidity of HIV-1 infected individuals were declined significantly by the introduction of highly active antiretroviral therapy (HAART). Nevertheless, different forms of HIV-associated neurocognitive ... -
Resveratrol Analogs: Potential Chemopreventive Agents in Breast Cancer
(2015-05-22)Epidemiological data and studies in rodent models strongly support the role of estrogens in the development of breast cancers. Estrogens have been added to the list of known human carcinogens. Exact mechanisms underlying ... -
Role of cytochrome P450 enzymes on alcohol/nicotine-mediated oxidative stress and cytotoxicity in monocytes/astrocytes: Implications for HIV-infected alcohol/tobacco users
(University of Missouri--Kansas City, 2012)Alcohol abuse is known to induce liver diseases and neurodegeneration. Chronic alcohol use during medication is known to decrease drug efficacy and increase toxicity. In addition, alcohol is known to interact with other ... -
Role of Redox-Active Trace Metal (RATM) Oxidants in the Regulation of Toll-Like Receptor 4 (TLR4) Signaling-Mediated Inflammatory Phenotype in Synovial Fibroblasts
(University of Missouri -- Kansas City, 2018)While the involvement of oxidant stress in rheumatoid arthritis (RA) has been suspected, the role of redox-active trace metals (RATM) as exogenous pro-oxidants in the pathogenesis of RA has not yet been investigated. ... -
Role of Toll-Like Receptor 4 in Oxidant-induced Inflammatory Phenotypes in Macrophages
(University of Missouri--Kansas City, 2017)A common mechanism by which redox stress may activate inflammatory responses to potentially initiate, propagate and maintain many diseases states has not been characterized. Accumulating evidence suggests that pattern ...