Browsing Division of Pharmaceutical Sciences (UMKC) by Thesis Advisor "Gutheil, William G. (William Glenn)"
Now showing items 1-5 of 5
-
Characterization of D-boroala as a novel Broad-spectrum antibacterial agent targeting D-Ala-D-Ala ligase & designer linkers : model reactions and linear free energy relationships in the reactivity and design of solid-phase linkers
(2014-07-18)Bacterial infections were the major cause of death and morbidity prior to the development of modern antibiotics, and the increasing resistance of pathogenic bacteria to commonly used antibacterial agents is a major public ... -
Library Screening and Focused Multiomics of Antibacterial Action on Vancomycin-Resistant Enterococci faecium
(2023)Antimicrobial resistance is a major public health threat, and there is an urgent need for new strategies to address this issue. In a gram-positive bacteria, the peptidoglycan layer is thick as compared to gram negatives ... -
Metabolomic Analysis of Bacterial Cell Wall Intermediates Using LC-MS/MS: Peptidoglycan Pathway Response to Different Antibiotics
(University of Missouri--Kansas City, 2017)The bacterial cell wall is made up of peptidoglycan (PG) and its synthesis is of interest as a target for several antibiotics and for new inhibitor development. Peptidoglycan biosynthesis is a complex process which ... -
Metabolomics and chemical library screening for antibacterial drug discovery
(2020)There are twenty standard amino acids which are proteinogenic and can exist in two stereoisomeric forms, D- and L-enantiomers, except for glycine, which is achiral. The D-amino acids are not incorporated in proteins; ... -
Structural and enzymatic characterization of bacterial cell wall enzymes: focus on penicillin-binding proteins
(2013)The research presented in this dissertation was aimed at understanding several structural and biochemical features underlying the bacterial cell wall biosynthetic process using statistical, biochemical and analytical tools. ...