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Formulation of nanoparticles encapsulating hydrophilic molecules following their ionic complexation
(University of Missouri--Kansas City, 2011-06-01)
Part 1: Dexamethasone is one of the most widely used drug molecules for the treatment of posterior segment ocular diseases. The major problems associated with the delivery of dexamethasone include its poor aqueous solubility ...
Nutrient Transporter targeted Delivery of HIV Protease Inhibitors
(University of Missouri--Kansas City, 2011-01-20)
HIV/AIDS has become one of the greatest threats to human health. Although inclusion of protease inhibitors (PIs) in HAART has greatly slowed the disease progression and improved the outcome of clinical treatment, the ...
Part I: The synthesis of chenodeoxycholic acid derived macrocyles and cage compounds. Part II. Sonogashira coupling for the synthesis of well-defined π-conjugated arylene ethynylene oligomers as blue-light-emitting materials
(University of Missouri--Kansas City, 2012-01-20)
The design and development of novel chenodeoxychoic acid (CDCA) derivatives and its molecular architecture was accomplished. A novel CDCA derivative with an ambient CO2 insertion to 7α-side chain has been serendipitously ...
Indole Arynes in organic synthesis : discovery and applications for the total synthesis of complex natural products
(University of Missouri -- Kansas City, 2011-05-03)
Arynes and heteroarynes are very important and useful reactive intermediates with many applications in organic synthesis, including natural products total synthesis. Although benzyne, the parent and most famous aryne, has ...
Sustained release nanoparticles containing acyclovir prodrugs for ocular herpes simplex keratitis and characterization of folate transport proteins in a corneal epithelial cell line
(University of Missouri-Kansas City, 2011-12-21)
Ocular herpes is a persistent viral infection caused by the herpes simplex virus-1. It is one of
the most common infectious diseases causing corneal blindness in the United States. In this
study, polymeric nanoparticles ...
Synthesis, morphologies and applications of polyoxometalate-containing diblock copolymers
(University of Missouri--Kansas City, 2012-01-31)
Block copolymers by virtue of their ability to self assemble and microphaseseparation
due to the contrast in chemical and physical properties of the covalently linked
blocks constitute the essential building blocks towards ...
Novel in vitro cell culture models for studying pharmacokinetic drug-drug interactions following oral administration
(University of Missouri--Kansas City, 2011-09-21)
In this study different in vitro models were developed to study the long term and short term drug- drug interactions occurring upon oral administration. MDCK cells were stably transfected for the simultaneous expression ...
Topical Nanoparticulate Formulation of Drugs for Ocular Keratitis
(2015-08-11)
The primary objective of this project is to develop drug-loaded polymeric nanoparticles
suspended in a biocompatible gel for topical delivery of therapeutic agents commonly
employed in the treatment of ocular viral/bacterial ...
Potential Mechanisms for Inhibition of Breast Cancer by Novel Azaresveratrol Analogs: Implications of Estrogen Receptor, Estrogen Metabolism and Cell Death Pathways
(2015-06-19)
Prolonged exposure to estrogens has been implicated in the development of breast cancers. Steroidal estrogens have been implicated in the initiation and progression of cancer. Estrogens bind to their cognate estrogen ...
Novel Polycyclic Benzannulated Indole Scaffolds via Indole Aryne Cycloaddition, Pd (0)-Catalyzed Cross-coupling and ROM/RCM methodologies: Their Applications to Library Development and Drug Discovery
(2014)
Dissertation under the direction of Keith R. Buszek, Ph.D., Professor of Chemistry,
University of Missouri-Kansas City.
Heterocyclic chemistry is one of the most valuable sources of novel compounds with
diverse biological ...
Topical Clear Aqueous Nanomicellar Formulations For Anterior And Posterior Ocular Drug Delivery
(2015-08-04)
The objective of this study was to develop a clear, aqueous drug loaded
nanomicellar formulation (NMF) for the back-of-the-eye delivery. Hydrophobic
drugs such as cyclosporine, resolvin analog (RX-10045), dexamethasone ...
HIV-1 gp120 and Methamphetamine-mediated Induction of Proinflammatory Cytokines/chemokines and Oxidative Stress in Astrocytes: Implications in Neuroinflammation
(2014-04-02)
HIV associated neurocognitive disorder (HAND) remains a major concern for patients infected with HIV. The viral envelope protein, gp120 has been extensively studied and some of its neurotoxic effects are due to the increased ...
Part I: Effect of Nanomicelle Size on Trans-scleral Permeability of Dexamethasone and Part II: Strategies to Minimize Octreotide Acylation during Sustained Release from Biodegradable Polymers
(2015-06-19)
Our primary aim was to determine the effect of nanomicelle size on dexamethasone (DEX) transport across the sclera. Nanomicelles of various sizes were developed and characterized.
Low molecular weight diblock co-polymers, ...
Proinflammatory Cytokine / Chemokine Expression in Human Astrocytes: Induction by HIV-1 Nef
(2014)
The mortality and morbidity of HIV-1 infected individuals were declined significantly by the introduction of highly active antiretroviral therapy (HAART). Nevertheless, different forms of HIV-associated neurocognitive ...
Light-activated biomacromolecules
(2013)
Biomacromolecules, mainly nucleic acids and proteins, are involved in
every cellular process and therefore their aberrant level or function is linked with
most of the diseases. Controlling these macromolecules using light ...
Total synthesis of (±)-cis-trikentrin B, (±)-herbindole A and (±)-herbindole B. investigation into the regioselectivity of 6,7-Indole aryne cycloadditions
(2013)
Total synthesis of benzannulated indole alkaloid natural products (±)-cis-trikentrin B,
(±)-herbindole A and (±)-herbindole B via intermolecular indole aryne cycloaddition are
described. The 5,6,7-tribromoindole was ...
Transporter-Targeted Prodrug Delivery to Improve Oral Bioavailability of Saquinavir
(2015-05-22)
Saquinavir (SQV) is the first antiretroviral protease inhibitor approved by Food and
Drug Administration in the United States for the treatment of HIV infection due to its
potent anti-HIV activity. However, some unfavorable ...
Evaluation of therapeutic effect of IKK epsilon SiRNA on breast cancer cells and development of a peptide-based SiRNA delivery system
(University of Missouri--Kansas City, 2012)
The objective of this dissertation is to develop siRNA-based cancer therapeutics. In
chapters 1 and 2, we introduced the mechanism, challenge and promise of RNAi-based
therapy, as well as various siRNA delivery systems. ...
Refinement and Applications of Light Controlled Biological Processes
(University of Missouri–Kansas City, 2015)
For understanding of biological processes, a spatiotemporal control over these processes is needed. Controlling these processes using light can give us the advantage of a precise control over spacing, timing and degree of ...
Characterization of D-boroala as a novel Broad-spectrum antibacterial agent targeting D-Ala-D-Ala ligase & designer linkers : model reactions and linear free energy relationships in the reactivity and design of solid-phase linkers
(2014-07-18)
Bacterial infections were the major cause of death and morbidity prior to the development of modern antibiotics, and the increasing resistance of pathogenic bacteria to commonly used antibacterial agents is a major public ...