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dc.contributor.authorHosu, Basarab Gabriel, 1968-eng
dc.contributor.authorJakab, Karoly Robert, 1974-eng
dc.contributor.authorBanki, Petereng
dc.contributor.authorToth, Ferenc I.eng
dc.contributor.authorForgács, Gabor, 1949-eng
dc.date.issued2003-06eng
dc.descriptiondoi:10.1063/1.1599066 http://rsi.aip.org/rsinak/v74/i9/p4158_s1eng
dc.description.abstractWe have designed and constructed a versatile magnetic tweezer primarily for intracellular investigations. The micromanipulator uses only two coils to simultaneously magnetize to saturation micron-size superparamagnetic particles and generate high magnitude constant field gradients over cellular dimensions. The apparatus resembles a miniaturized Faraday balance, an industrial device used to measure magnetic susceptibility. The device operates in both continuous and pulse modes. Due to its compact size, the tweezers can conveniently be mounted on the stage of an inverted microscope and used for intracellular manipulations. A built-in temperature control unit maintains the sample at physiological temperatures. The operation of the tweezers was tested by moving 1.28 μm diameter magnetic beads inside macrophages with forces near 500 pN.eng
dc.description.sponsorshipThis work was partially supported by the NSF ~Grant No. DBI-9730999!.eng
dc.identifier.citationRev. Sci. Instrum. 74, 4158 (2003)eng
dc.identifier.issn0034-6748eng
dc.identifier.urihttp://hdl.handle.net/10355/8051eng
dc.publisherAmerican Institute of Physicseng
dc.relation.ispartofPhysics and Astronomy publicationseng
dc.relation.ispartofcommunityUniversity of Missouri-Columbia. College of Arts and Sciences. Department of Physics and Astronomyeng
dc.subjectmicromanipulatorseng
dc.subjectsubcellular structure and processeseng
dc.subject.lcshCell nuclei -- Transplantationeng
dc.subject.lcshTissue engineeringeng
dc.subject.lcshBiotechnologyeng
dc.subject.lcshMagnetic fieldseng
dc.subject.lcshCell compartmentationeng
dc.titleMagnetic tweezers for intracellular applicationseng
dc.typeArticleeng


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