Shared more. Cited more. Safe forever.
    • advanced search
    • submit works
    • about
    • help
    • contact us
    • login
    View Item 
    •   MOspace Home
    • University of Missouri-Columbia
    • Office of Undergraduate Research (MU)
    • Undergraduate Research and Creative Achievements Forum (MU)
    • 2005 Undergraduate Research and Creative Achievements Forum (MU)
    • View Item
    •   MOspace Home
    • University of Missouri-Columbia
    • Office of Undergraduate Research (MU)
    • Undergraduate Research and Creative Achievements Forum (MU)
    • 2005 Undergraduate Research and Creative Achievements Forum (MU)
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.
    advanced searchsubmit worksabouthelpcontact us

    Browse

    All of MOspaceCommunities & CollectionsDate IssuedAuthor/ContributorTitleIdentifierThesis DepartmentThesis AdvisorThesis SemesterThis CollectionDate IssuedAuthor/ContributorTitleIdentifierThesis DepartmentThesis AdvisorThesis Semester

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular AuthorsStatistics by Referrer

    Bisphenol A alters messenger RNA expression in prostate mesenchyme cells [abstract]

    Kirkpatrick, James R., 1983-
    Stone, Derica
    View/Open
    [PDF] Bisphenol A alters messenger RNA (Kirkpatrick abstract).pdf (27.07Kb)
    [PDF] Bisphenol A alters messenger RNA (Stone abstract).pdf (27.22Kb)
    Date
    2005
    Contributor
    University of Missouri-Columbia. Office of Undergraduate Research
    Format
    Abstract
    Metadata
    [+] Show full item record
    Abstract
    Exposure to abnormal levels of estrogen and estrogen-mimicking chemicals during fetal life can alter proper development of tissues. These alterations are initiated during fetal life and include increased adult predisposition to cancer, heightened tendency towards obesity, earlier onset of puberty in females, decreased sperm count in males, and affected normal tissue growth. The prostate is a tissue that is sensitive to alterations in sex hormone levels during development. The development of this tissue is androgen-dependent, but can also be influenced by estrogens. Experiments have shown that fetal exposure to estrogen and estrogen-mimicking chemicals alters prostate growth in mice, but the molecular mechanism by which this occurs is still unclear. In order to answer the above question, this study looked at alterations in gene expression in the mesenchyme of the developing prostate due to exposure to different amounts of estradiol (E2) and the estrogen-mimicking chemical bisphenol A (BPA). The mesenchyme tissues were collected from male fetuses on gestation day 17. These cells were cultured and treated with varying concentrations of E2 and BPA. We examined gene expression of the androgen receptor (AR), estrogen receptor (ER), and insulin-like growth factor-1 (IGF-1). Over the dose range studied, BPA caused an increase in AR (1.6 fold), ER (2.85 fold) and IGF-1 (2.5 fold). E2 increased AR (2.2 fold) and ER (3.36 fold) gene expression, but did not effect IGF-1 gene expression. Our findings show how development of the prostate may be regulated by alterations to estrogen levels in the body. They also show how environmental chemicals can have a disruptive effect on tissue by inducing changes in the expression of certain genes.
    URI
    http://hdl.handle.net/10355/809
    Part of
    2005 Undergraduate Research and Creative Achievements Forum (MU)
    Collections
    • 2005 Undergraduate Research and Creative Achievements Forum (MU)

    Send Feedback
    hosted by University of Missouri Library Systems
     

     


    Send Feedback
    hosted by University of Missouri Library Systems