Determining the spatial and temporal requirement of the dunce cAMP-phosphodiesterase in behavior [abstract]

Abstract

One of the first genes identified as affecting learning in Drosophila was the dunce cAMP-phosphodiesterase (PDE). Molecular lesions and transgenic rescue firmly identified the dunce-PDE as the cause for decreased learning in mutant flies (Dauwalder and Davis, 1995). Despite the critical function of the dunce products in memory formation, little is known of the spatial and temporal requirements of dunce gene product in memory formation. We have generated the tools to address this problem.