Biomimetic reactions relevant to the study of abasic sites in DNA
Abasic (Ap) sites represent the most common form of DNA damage in mammalian cells. With steady state levels of 10,000 sites existing in each cell, there is a dire need to study these noxious biological electrophiles. While much work has been done to study these lesions using small biomolecules, such as oligonucleotides, there is still much to be learned regarding the fundamental organic chemistry. This thesis attempts to use the tools of basic organic chemistry to understand the complex reactions, structure, and equilibria of the abasic site.