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Chronic Fibrotic Changes in Experimental Pulmonary Embolization in the Rat Model
(2010-03)
Introduction: Fat embolism, a subclinical event, occurs in many clinical settings, such as long bones fractures, liposuction and during cardiopulmonary bypass. Some cases, especially with trauma, result in fat embolism ...
Clearing the hurdles for nanotechnology: In vivo inhalation effects
(2010-03)
INTRODUCTION: Nanoparticles of many types have been created for industrial and medical applications. Among these nanoparticles, single-walled carbon nanotubes (SWCNT) are of high interest for their physicochemical properties ...
Regulation of Phosphorylation of Dopamine D3 Receptors in Mouse Striatal Neurons in vivo
(2010-03)
Introduction: Dopamine D3 receptors (D3Rs) are G-protein-coupled receptors. These D3Rs inhibit adenylyl cyclase and the downstream formation of cAMP. Due to their preferential expression in the mesolimbic areas, especially ...
Amphetamine Alters Acid-Sensing Ion Channel Expression in the Rat Striatum
(2010-03)
Introduction: The acid-sensing ion channel (ASIC) is specifically activated by a drop in the extracellular pH level. These channels are widely expressed in mammalian brains and actively modulate synaptic transmission and ...
Amphetamine Alters Group I mGluR Expression in the Rat Striatum and Medial Prefrontal Cortex
(2010-03)
Introduction: Group I metabotropic glutamate receptors (mGluR1/mGluR5 subtypes) and their key scaffolding protein Homer1b/c are densely expressed in the striatum. These receptors are believed to play important roles in ...
Effects of Isoflurane on Plasma-Membrane Calcium ATPase
(2010-03)
Introduction: Plasma membrane Ca2+-ATPase (PMCA) is a transmembrane enzymatic protein present in human neurons, myocytes, and RBCs which plays a role in controlling cellular Ca2+ levels by regulating intracellular ATP. ...
Toxicty of a Serotonin-derived Neuromelanin
(2010)
Introduction: POCD (Postoperative Cognitive Dysfunction) is associated with increased mortality and disability and may develop as a consequence of lipid peroxidative byproducts (i.e. acrolein), which accumulate with aging. ...