Department of Basic Medical Science (UMKC): Recent submissions
Now showing items 1-20 of 20
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RNA-seq analysis of synovial fibroblasts brings new insights into rheumatoid arthritis
(2012-12-21)Abstract Background Rheumatoid arthritis (RA) is a chronic autoimmune-disease of unknown origin that primarily affects the joints and ultimately leads to their destruction. Growing evidence ... -
Associations between the built environment and physical activity in public housing residents
(2007-11-12)Abstract Background Environmental factors may influence the particularly low rates of physical activity in African American and low-income adults. This cross-sectional study investigated ... -
Gene selection for classification of microarray data based on the Bayes error
(2007-10-03)Abstract Background With DNA microarray data, selecting a compact subset of discriminative genes from thousands of genes is a ... -
HAPSIMU: a genetic simulation platform for population-based association studies
(2008-08-05)Abstract Background Population structure is an important cause leading to inconsistent results in population-based association ... -
The neuroprotective properties of palmitoylethanolamine against oxidative stress in a neuronal cell line
(2009-12-10)Abstract Background N-acylethanolamines (NAEs) are lipids upregulated in response to cell and tissue injury and are involved ... -
A new permutation strategy of pathway-based approach for genome-wide association study
(2009-12-18)Abstract Background Recently introduced pathway-based approach is promising and advantageous to improve the efficiency of ... -
Tocotrienols inhibit lipopolysaccharide-induced pro-inflammatory cytokines in macrophages of female mice.
(2010-12-16)Abstract Background Inflammation has been implicated in cardiovascular disease, and the important role of proteasomes in the development of inflammation and other macrophage functions has been demonstrated. ... -
delta-Tocotrienol and quercetin reduce serum levels of nitric oxide and lipid parameters in female chickens
(2011-02-28)Abstract Background Chronic, low-grade inflammation provides a link between normal ageing and the pathogenesis of age-related diseases. A series of in vitro tests confirmed the strong anti-inflammatory activities ... -
A Bayesian Analysis for Identifying DNA Copy Number Variations Using a Compound Poisson Process
(2010-08-17)To study chromosomal aberrations that may lead to cancer formation or genetic diseases, the array-based Comparative Genomic Hybridization (aCGH) technique is often used for detecting DNA copy number variants (CNVs). Various ... -
Tocotrienols-induced inhibition of platelet thrombus formation and platelet aggregation in stenosed canine coronary arteries.
(2011-04-14)Abstract Background Dietary supplementation with tocotrienols has been shown to decrease the risk of coronary artery disease. Tocotrienols are plant-derived forms of vitamin E, which have potent anti-inflammatory, ... -
Inhibition of nitric oxide and inflammatory cytokines in LPS-stimulated murine macrophages by resveratrol, a potent proteasome inhibitor
(2012-06-14)Abstract Background: Altered immune function during ageing results in increased production of nitric oxide (NO) and other inflammatory mediators. Recently, we have reported that NO production was inhibited ... -
Inhibition of nitric oxide in LPS-stimulated macrophages of young and senescent mice by delta-tocotrienol and quercetin.
(2011-12-20)Abstract Background Changes in immune function believed to contribute to a variety of age-related diseases have been associated with increased production of nitric oxide (NO). We have recently reported that ... -
Suppression of nitric oxide induction and pro-inflammatory cytokines by novel proteasome inhibitors in various experimental models
(2011-10-12)Abstract Background Inflammation has been implicated in a variety of diseases associated with ageing, including cancer, cardiovascular, and neurologic diseases. We have recently established that the proteasome ... -
Regulation of Phosphorylation of Dopamine D3 Receptors in Mouse Striatal Neurons in vivo
(2010-03)Introduction: Dopamine D3 receptors (D3Rs) are G-protein-coupled receptors. These D3Rs inhibit adenylyl cyclase and the downstream formation of cAMP. Due to their preferential expression in the mesolimbic areas, especially ... -
Amphetamine Alters Group I mGluR Expression in the Rat Striatum and Medial Prefrontal Cortex
(2010-03)Introduction: Group I metabotropic glutamate receptors (mGluR1/mGluR5 subtypes) and their key scaffolding protein Homer1b/c are densely expressed in the striatum. These receptors are believed to play important roles in ... -
Amphetamine Alters Acid-Sensing Ion Channel Expression in the Rat Striatum
(2010-03)Introduction: The acid-sensing ion channel (ASIC) is specifically activated by a drop in the extracellular pH level. These channels are widely expressed in mammalian brains and actively modulate synaptic transmission and ... -
Chronic Fibrotic Changes in Experimental Pulmonary Embolization in the Rat Model
(2010-03)Introduction: Fat embolism, a subclinical event, occurs in many clinical settings, such as long bones fractures, liposuction and during cardiopulmonary bypass. Some cases, especially with trauma, result in fat embolism ... -
Clearing the hurdles for nanotechnology: In vivo inhalation effects
(2010-03)INTRODUCTION: Nanoparticles of many types have been created for industrial and medical applications. Among these nanoparticles, single-walled carbon nanotubes (SWCNT) are of high interest for their physicochemical properties ... -
Acid-sensing ion channels as a novel target for drug addiction [abstract]
(2010-03)Improving the treatment and prevention of drug addiction is an important goal for modern medicine. Ion channels have recently become very attractive targets in the search of new pharmacotherapies. Extracellular proton ... -
Skeletal Muscle - Bone Crosstalk Regulating Osteocyte Function [abstract]
(2010-03)Osteocytes are thought to be the primary cell in bone that responds to mechanical loading and the traditional view is that skeletal muscle's role relative to bone is in the application of those loads. We have hypothesized ...