Shared more. Cited more. Safe forever.
    • advanced search
    • submit works
    • about
    • help
    • contact us
    • login
    View Item 
    •   MOspace Home
    • University of Missouri-Columbia
    • Graduate School - MU Theses and Dissertations (MU)
    • Theses and Dissertations (MU)
    • Dissertations (MU)
    • 2010 Dissertations (MU)
    • 2010 MU dissertations - Access restricted to MU
    • View Item
    •   MOspace Home
    • University of Missouri-Columbia
    • Graduate School - MU Theses and Dissertations (MU)
    • Theses and Dissertations (MU)
    • Dissertations (MU)
    • 2010 Dissertations (MU)
    • 2010 MU dissertations - Access restricted to MU
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.
    advanced searchsubmit worksabouthelpcontact us

    Browse

    All of MOspaceCommunities & CollectionsDate IssuedAuthor/ContributorTitleIdentifierThesis DepartmentThesis AdvisorThesis SemesterThis CollectionDate IssuedAuthor/ContributorTitleIdentifierThesis DepartmentThesis AdvisorThesis Semester

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular AuthorsStatistics by Referrer

    Characterization of skeletal muscle in mouse models of osteogenesis imperfecta and myostatin deficiency

    Weber, Bettina A., 1979-
    View/Open
    [PDF] public.pdf (2.500Kb)
    [PDF] short.pdf (76.49Kb)
    [PDF] research.pdf (4.370Mb)
    Date
    2010
    Format
    Thesis
    Metadata
    [+] Show full item record
    Abstract
    [ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Osteogenesis imperfecta (OI) is a heritable connective tissue disorder hallmarked by bone fragility resulting primarily from mutations in the pro[alpha]1(I) or pro[alpha]2(I) collagen genes. Muscle weakness is an often-reported, little-investigated concern of patients with OI. We examined the soleus (S), plantaris (P), gastrocnemius (G), tibialis anterior (TA) and quadriceps (Q) muscles of mice expressing mild (+/oim and +/G610C) and moderately severe (oim/oim) OI for evidence of inherent muscle pathology. Four month old oim/oim mouse muscles were generally smaller, had weaker muscles and an inability to sustain Po for the 300 ms testing duration for specific muscles; +/oim mice had a similar but milder skeletal muscle phenotype. Though four month old +/G610C mice had significant changes in the relative wet weights of the Q muscle (males) and S and G muscles (females) compared with same sex wt mice, their muscles were not weaker compared to their same sex wildtype (wt) counterparts. We next investigated the effects of exercise on skeletal muscle and bone. We found that oim/oim mice could not tolerate impact exercise but that +/oim mice responded similarly to exercise as wt mice, with modest improvements in bone biomechanical integrity. Lastly, we characterized the skeletal muscle in male and female myostatin (MSTN) deficient mice. Absence of functional MSTN during fetal development results in adult skeletal muscle hypertrophy and hyperplasia. Visible pathology in male Mstn -/- mice and decreased contractile strength relative to increased muscle weight suggest MSTN loss results in muscle impairment which is dose, sex and muscle dependent.
    URI
    https://hdl.handle.net/10355/8435
    https://doi.org/10.32469/10355/8435
    Degree
    Ph. D.
    Thesis Department
    Veterinary pathobiology area program (MU)
    Rights
    Access is limited to the campus of the University of Missouri-Columbia.
    This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License.
    Collections
    • Veterinary Pathobiology electronic theses and dissertations (MU)
    • 2010 MU dissertations - Access restricted to MU

    Send Feedback
    hosted by University of Missouri Library Systems
     

     


    Send Feedback
    hosted by University of Missouri Library Systems