dc.contributor.advisor | Robertson, John David, 1960- | eng |
dc.contributor.author | Wang, Xiaowei, 1978- | eng |
dc.date.issued | 2010 | eng |
dc.date.submitted | 2010 Spring | eng |
dc.description | The entire thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file; a non-technical public abstract, appears in the public.pdf file. | eng |
dc.description | Title from PDF of title page (University of Missouri--Columbia, viewed on August 23, 2010). | eng |
dc.description | Thesis advisor: Dr. J. David Robertson. | eng |
dc.description | Ph. D. University of Missouri--Columbia 2010. | eng |
dc.description.abstract | [ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Cisplatin (cDDP), the first platinum chemotherapy compound, has been used in cancer chemotherapy in human beings and animals for more than thirty years. Satraplatin (JM216), the first oral-administrated anti-tumor platinum compound, shows potential in treating solid tumors with low toxicity in clinical trials. The first objective of this work was to develop and apply analytical procedures to determine the maximally tolerated dose of satraplatin, its efficacy, safety and pharmacokinetics in dogs. This work also aimed to better understand the mechanism of cisplatin cell resistance by investigating cisplatin uptake in different human embryo kidney (HEK) cells. In this study, a robust and highly sensitivity experimental quadrupole ICP-MS methodology was developed and used to analyze platinum and copper in biological matrices and acid-assistant closed-vessel microwave digestion and heated sonic water bath digestion were used for sample preparation. | eng |
dc.description.bibref | Includes bibliographical references. | eng |
dc.format.extent | xviii, 153 pages | eng |
dc.identifier.merlin | b77891685 | eng |
dc.identifier.oclc | 657376152 | eng |
dc.identifier.uri | https://hdl.handle.net/10355/8443 | |
dc.identifier.uri | https://doi.org/10.32469/10355/8443 | eng |
dc.language | English | eng |
dc.publisher | University of Missouri--Columbia | eng |
dc.relation.ispartofcommunity | University of Missouri--Columbia. Graduate School. Theses and Dissertations | eng |
dc.rights | Access is limited to the campuses of the University of Missouri. | eng |
dc.rights.license | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License. | |
dc.subject.lcsh | Cisplatin | eng |
dc.subject.lcsh | Platinum compounds -- Therapeutic use -- Administration | eng |
dc.subject.lcsh | Oral medication | eng |
dc.subject.lcsh | Cancer -- Chemotherapy | eng |
dc.subject.lcsh | Antineoplastic agents | eng |
dc.title | Development and application of inductively coupled plasma mass spectrometry techniques to investigate platinum chemotherapy agents | eng |
dc.type | Thesis | eng |
thesis.degree.discipline | Chemistry (MU) | eng |
thesis.degree.grantor | University of Missouri--Columbia | eng |
thesis.degree.level | Doctoral | eng |
thesis.degree.name | Ph. D. | eng |