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dc.contributor.advisorRobertson, John David, 1960-eng
dc.contributor.authorWang, Xiaowei, 1978-eng
dc.date.issued2010eng
dc.date.submitted2010 Springeng
dc.descriptionThe entire thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file; a non-technical public abstract, appears in the public.pdf file.eng
dc.descriptionTitle from PDF of title page (University of Missouri--Columbia, viewed on August 23, 2010).eng
dc.descriptionThesis advisor: Dr. J. David Robertson.eng
dc.descriptionPh. D. University of Missouri--Columbia 2010.eng
dc.description.abstract[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Cisplatin (cDDP), the first platinum chemotherapy compound, has been used in cancer chemotherapy in human beings and animals for more than thirty years. Satraplatin (JM216), the first oral-administrated anti-tumor platinum compound, shows potential in treating solid tumors with low toxicity in clinical trials. The first objective of this work was to develop and apply analytical procedures to determine the maximally tolerated dose of satraplatin, its efficacy, safety and pharmacokinetics in dogs. This work also aimed to better understand the mechanism of cisplatin cell resistance by investigating cisplatin uptake in different human embryo kidney (HEK) cells. In this study, a robust and highly sensitivity experimental quadrupole ICP-MS methodology was developed and used to analyze platinum and copper in biological matrices and acid-assistant closed-vessel microwave digestion and heated sonic water bath digestion were used for sample preparation.eng
dc.description.bibrefIncludes bibliographical references.eng
dc.format.extentxviii, 153 pageseng
dc.identifier.merlinb77891685eng
dc.identifier.oclc657376152eng
dc.identifier.urihttps://hdl.handle.net/10355/8443
dc.identifier.urihttps://doi.org/10.32469/10355/8443eng
dc.languageEnglisheng
dc.publisherUniversity of Missouri--Columbiaeng
dc.relation.ispartofcommunityUniversity of Missouri--Columbia. Graduate School. Theses and Dissertationseng
dc.rightsAccess is limited to the campuses of the University of Missouri.eng
dc.rights.licenseThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License.
dc.subject.lcshCisplatineng
dc.subject.lcshPlatinum compounds -- Therapeutic use -- Administrationeng
dc.subject.lcshOral medicationeng
dc.subject.lcshCancer -- Chemotherapyeng
dc.subject.lcshAntineoplastic agentseng
dc.titleDevelopment and application of inductively coupled plasma mass spectrometry techniques to investigate platinum chemotherapy agentseng
dc.typeThesiseng
thesis.degree.disciplineChemistry (MU)eng
thesis.degree.grantorUniversity of Missouri--Columbiaeng
thesis.degree.levelDoctoraleng
thesis.degree.namePh. D.eng


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