Shared more. Cited more. Safe forever.
    • advanced search
    • submit works
    • about
    • help
    • contact us
    • login
    View Item 
    •   MOspace Home
    • University of Missouri-Columbia
    • College of Veterinary Medicine (MU)
    • Department of Veterinary Pathobiology (MU)
    • Veterinary Pathobiology publications (MU)
    • View Item
    •   MOspace Home
    • University of Missouri-Columbia
    • College of Veterinary Medicine (MU)
    • Department of Veterinary Pathobiology (MU)
    • Veterinary Pathobiology publications (MU)
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.
    advanced searchsubmit worksabouthelpcontact us

    Browse

    All of MOspaceCommunities & CollectionsDate IssuedAuthor/ContributorTitleIdentifierThesis DepartmentThesis AdvisorThesis SemesterThis CollectionDate IssuedAuthor/ContributorTitleIdentifierThesis DepartmentThesis AdvisorThesis Semester

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular AuthorsStatistics by Referrer

    Differential Susceptibility of SD and CD Rats to a Novel Rat Theilovirus

    Drake, Michael T.
    Riley, Lela K. (Lela Kay)
    Livingston, Robert Schaad, 1964-
    View/Open
    [PDF] DifferentialSusceptibilitySDCDRats.pdf (6.534Mb)
    Date
    2008
    Format
    Article
    Metadata
    [+] Show full item record
    Abstract
    Antibodies to rat theilovirus (RTV) have been detected in rats for many years because of their serologic crossreactivity with strains of Theiler murine encephalomyelitis virus (TMEV) of mice. Little information exists regarding this pathogen, yet it is among the most common viruses detected in serologic surveys of rats used in research. In the study reported here, a novel isolate of RTV, designated RTV1, was cultured from the feces of infected rats. The RTV1 genome contained 8094 nucleotides and had approximately 95% identity with another rat theilovirus, NSG910, and 73% identity with TMEV strains. In addition, the genome size of RTV1 was similar to those of TMEV strains but larger than that reported for NSG910. Oral inoculation of Sprague-Dawley (SD) and CD male rats (n = 10 each group) with RTV1 revealed that SD rats were more susceptible than CD rats to RTV1 infection. At 14 d postinoculation, 100% of SD rats shed virus in the feces, and 70% were positive for RTV serum antibodies. By 56 d postinoculation 30% of SD rats continued to have detectable virus in the feces, and 90% had seroconverted. In contrast, in inoculated CD rats RTV was detected only in the feces at 14 d postinoculation, at which time 40% of CD rats were fecal positive. By 56 d postinoculation only 20% of CD rats had detectable RTV serum antibodies. Our data provide additional sequence information regarding a rat-specific Cardiovirus and indicate that SD rats are more susceptible than CD rats to RTV1 infection.
    URI
    http://hdl.handle.net/10355/8481
    Part of
    Veterinary Pathobiology publications (MU)
    Citation
    Drake, M.T., Riley, L.K., and Livingston, R.S. (2008). Differential Susceptibility of SD and CD Rats to a Novel Rat Theilovirus. Comparative Medicine, 58(5), 458-464.
    Collections
    • Veterinary Pathobiology publications (MU)

    Send Feedback
    hosted by University of Missouri Library Systems
     

     


    Send Feedback
    hosted by University of Missouri Library Systems