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Ultrastructural Islet Study of Early Fibrosis in the Ren2 Rat Model of Hypertension Emerging Role of the Islet Pancreatic Pericyte-Stellate Cell
(Journal of the Pancreas, 2007)
Type 2 diabetes mellitus is a multifactorial disease with polygenic and environmental stressors resulting in multiple metabolic toxicities and islet oxidative stress. We have integrated the role of the islet renin-angiotensin ...
Mineralocorticoid Receptor Blockade Attenuates Chronic Overexpression of the Renin-Angiotensin- Aldosterone System Stimulation of Reduced Nicotinamide Adenine Dinucleotide Phosphate Oxidase and Cardiac Remodeling
(Endocrinology, 2007-08)
The renin-angiotensin-aldosterone system contributes to cardiac remodeling, hypertrophy, and left ventricular dysfunction.
Angiotensin II and aldosterone (corticosterone in rodents) together generate reactive oxygen species ...