Ultrastructural Islet Study of Early Fibrosis in the Ren2 Rat Model of Hypertension Emerging Role of the Islet Pancreatic Pericyte-Stellate Cell

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Ultrastructural Islet Study of Early Fibrosis in the Ren2 Rat Model of Hypertension Emerging Role of the Islet Pancreatic Pericyte-Stellate Cell

Please use this identifier to cite or link to this item: http://hdl.handle.net/10355/8498

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Title: Ultrastructural Islet Study of Early Fibrosis in the Ren2 Rat Model of Hypertension Emerging Role of the Islet Pancreatic Pericyte-Stellate Cell
Author: Hayden, Melvin; Karuparthi, Poorna R.; Habibi, Javad, 1947-; Wasekar, Chetan; Lastra, Guido; Manrique, Camilla; Stas, Sameer; Sowers, James R. (James Russell), 1942-
Date: 2007
Publisher: Journal of the Pancreas
Citation: Ultrastructural Islet Study of Early Fibrosis in the Ren2 Rat Model of Hypertension Emerging Role of the Islet Pancreatic Pericyte-Stellate Cell. Journal of the Pancreas, 8(6), 725-738.
Abstract: Type 2 diabetes mellitus is a multifactorial disease with polygenic and environmental stressors resulting in multiple metabolic toxicities and islet oxidative stress. We have integrated the role of the islet renin-angiotensin system (RAS) in the pathogenesis of early islet fibrosis utilizing the transgenic (mRen2)27 rodent model of hypertension and tissue RAS overexpression. The Ren2 pancreatic islet tissue was evaluated with transmission electron microscopy to study both early cellular and extracellular matrix remodeling. Major remodeling differences in the Ren2 model were found to be located within the islet exocrine interface, including deposition of early fibrillar-banded collagen (fibrosis) and cellular remodeling of the pericyte suggesting proliferation, migration, hypertrophy and activation as compared to the Sprague Dawley controls.
URI: http://hdl.handle.net/10355/8498
ISSN: 1590-8577

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  • Endocrinology publications (MU) [2]
    The items in this collection are the scholarly output of the faculty, staff, and students of the Division of Endocrinology.

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