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    Ultrastructural Islet Study of Early Fibrosis in the Ren2 Rat Model of Hypertension Emerging Role of the Islet Pancreatic Pericyte-Stellate Cell

    Hayden, Melvin
    Karuparthi, Poorna R.
    Habibi, Javad, 1947-
    Wasekar, Chetan
    Lastra, Guido
    Manrique, Camilla
    Stas, Sameer
    Sowers, James R. (James Russell), 1942-
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    [PDF] UltrastructuralIsletStudyEarlyFibrosis.pdf (1.332Mb)
    Date
    2007
    Format
    Article
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    Abstract
    Type 2 diabetes mellitus is a multifactorial disease with polygenic and environmental stressors resulting in multiple metabolic toxicities and islet oxidative stress. We have integrated the role of the islet renin-angiotensin system (RAS) in the pathogenesis of early islet fibrosis utilizing the transgenic (mRen2)27 rodent model of hypertension and tissue RAS overexpression. The Ren2 pancreatic islet tissue was evaluated with transmission electron microscopy to study both early cellular and extracellular matrix remodeling. Major remodeling differences in the Ren2 model were found to be located within the islet exocrine interface, including deposition of early fibrillar-banded collagen (fibrosis) and cellular remodeling of the pericyte suggesting proliferation, migration, hypertrophy and activation as compared to the Sprague Dawley controls.
    URI
    http://hdl.handle.net/10355/8498
    Part of
    Endocrinology publications (MU)
    Citation
    Ultrastructural Islet Study of Early Fibrosis in the Ren2 Rat Model of Hypertension Emerging Role of the Islet Pancreatic Pericyte-Stellate Cell. Journal of the Pancreas, 8(6), 725-738.
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    • Endocrinology publications (MU)

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