Influence of Gold Nanoparticles on Collagen Fibril Morphology Quantified Using Transmission Electron Microscopy and Image Analysis

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Influence of Gold Nanoparticles on Collagen Fibril Morphology Quantified Using Transmission Electron Microscopy and Image Analysis

Please use this identifier to cite or link to this item: http://hdl.handle.net/10355/8502

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Title: Influence of Gold Nanoparticles on Collagen Fibril Morphology Quantified Using Transmission Electron Microscopy and Image Analysis
Author: Haidekker, Mark A., 1963-; Boettcher, Lisa W.; Suter, Jonathan Daniel, 1982-; Rone, Rebecca; Grant, Sheila Ann
Keywords: TEM
run length analysis
topology analysis
collagen fibril formation
Date: 2006-05-31
Publisher: BMC Medical Imaging
Citation: BMC Medical Imaging 2006, 6:4
Abstract: Development of implantable biosensors for disease detection is challenging because of poor biocompatibility of synthetic materials. A possible solution involves engineering interface materials that promote selfassembly and adhesion of autologous cells on sensor surfaces. Crosslinked type-I collagen is an acceptable material for developing engineered basement membranes. In this study, we used functionalized gold nanoparticles as the crosslinking agent. Functionalized nanoparticles provide sites for crosslinking collagen as well as sites to deliver signaling compounds that direct selfassembly and reduce inflammation. The goal of this study was to obtain a quantitative parameter to objectively determine the presence of crosslinks.
URI: http://hdl.handle.net/10355/8502
Other Identifiers: doi:10.1186/1471-2342-6-4

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