[-] Show simple item record

dc.contributor.authorWilliams, Bryan J.eng
dc.contributor.authorGolomb, Miriameng
dc.contributor.authorPhillips, Thomaseng
dc.contributor.authorBrownlee, Joshuaeng
dc.contributor.authorOlson, Maynardeng
dc.contributor.authorSmith, Arnold L.eng
dc.date.issued2002eng
dc.descriptionDOI: 10.1128/JB.184.24.6893-6905.2002eng
dc.description.abstractTemperate bacteriophages effect chromosomal evolution of their bacterial hosts, mediating rearrangements and the acquisition of novel genes from other taxa. Although the Haemophilus influenzae genome shows evidence of past phage-mediated lateral transfer, the phages presumed responsible have not been identified. To date, six different H. influenzae phages are known; of these, only the HP1/S2 group, which lyosogenizes exclusively Rd strains (which were originally encapsulated serotype d), is well characterized. Phages in this group are genetically very similar, with a highly conserved set of genes. Because the majority of H. influenzae strains are nonencapsulated (nontypeable), it is important to characterize phages infecting this larger, genetically more diverse group of respiratory pathogens. We have identified and sequenced HP2, a bacteriophage of nontypeable H. influenzae. Although related to the fully sequenced HP1 (and even more so to the partially sequenced S2) and similar in genetic organization, HP2 has a few novel genes and differs in host range; HP2 will not infect or lysogenize Rd strains. Genomic comparisons between HP1/S2 and HP2 suggest recent divergence, with new genes completely replacing old ones at certain loci. Sequence comparisons suggest that H. influenzae phages evolve by recombinational exchange of genes with each other, with cryptic prophages, and with the host chromosome.eng
dc.description.sponsorshipThis work was supported by NIH grants AI44002 and T32 AI07276 to A. L. Smith.eng
dc.identifier.citationJournal of Bacteriology, December 2002, p. 6893-6905, Vol. 184, No. 24.eng
dc.identifier.issn0021-9193/02eng
dc.identifier.urihttp://hdl.handle.net/10355/8610eng
dc.languageEnglisheng
dc.publisherAmerican Society for Microbiologyeng
dc.relation.ispartofBiological Sciences publications (MU)eng
dc.relation.ispartofcommunityUniversity of Missouri-Columbia. College of Arts and Sciences. Division of Biological Scienceseng
dc.source.harvestedhttp://jb.asm.org/cgi/reprint/184/24/6893?maxtoshow=&hits=10&RESULTFORMAT=&fulltext=codons&searchid=1&FIRSTINDEX=1850&resourcetype=HWFIGeng
dc.subject.lcshBacteriophageseng
dc.subject.lcshHaemophilus influenzaeeng
dc.subject.lcshDNA -- Analysiseng
dc.titleBacteriophage HP2 of Haemophilus influenzaeeng
dc.typeArticleeng


Files in this item

[PDF]

This item appears in the following Collection(s)

[-] Show simple item record