Biomedical Sciences publications (MU)

 

Items in this collection are the scholarly output of the Department of Biomedical Sciences faculty, staff, and students, either alone or as co-authors, and which may or may not have been published in an alternate format. Items may contain more than one file type.

Items in MOspace are protected by copyright, with all rights reserved, unless otherwise indicated.

Recent Submissions

  • APR-246 alone and in combination with a phosphatidylserine-targeting antibody inhibits lung metastasis of human triple-negative breast cancer cells in nude mice 

    Liang, Y.; Besch-Williford, C.; Cook, M.T.; Belenchia, A.; Brekken, R.A.; Hyder, S.M. (Dove Medical Press Ltd., 2019)
    Background: Approximately 15-20 percent of all human breast cancers are classified as triple-negative because they lack estrogen and progesterone receptors and Her-2-neu, which are commonly targeted by chemotherapeutic ...

  • Endurance exercise training does not limit coronary atherosclerosis in familial hypercholesterolemic swine 

    Tharp, D.L.; Masseau, I.; Ivey, J.; Laughlin, M.H.; Bowles, D.K. (American Physiological Society, 2019)
    Human studies demonstrate that physical activity reduces both morbidity and mortality of coronary heart disease (CHD) including decreased progression and/or regression of CHD with life-style modification which includes ...

  • Rats selectively bred for high voluntary physical activity behavior are not protected from the deleterious metabolic effects of a Western diet when sedentary 

    Heese, A. J.; Roberts, C. K.; Hofheins, J. C.; Brown, J. D.; Ruegsegger, G. N.; Toedebusch, R. G.; Booth, F. W. (Oxford University Press, 2019)
    Background: Physical activity and diet are well-established modifiable factors that influence chronic disease risk. We developed a selectively bred, polygenic model for high and low voluntary running (HVR and LVR, respectively) ...

  • A BAC transgene expressing human CFTR under control of its regulatory elements rescues Cftr knockout mice 

    Gawenis L. R.; Hodges C. A.; McHugh D. R.; Valerio D. M.; Miron A.; Cotton C. U.; Liu J.; Walker N. M.; Strubberg A. M.; Gillen A. E.; Mutolo M. J.; Kotzamanis G.; Bosch J.; Harris A.; Drumm M. L.; Clarke L. L. (Nature Publishing Group, 2019)
    Small-molecule modulators of cystic fibrosis transmembrane conductance regulator (CFTR) biology show promise in the treatment of cystic fibrosis (CF). A Cftr knockout (Cftr KO) mouse expressing mutants of human CFTR would ...

  • Sedentary death syndrome is what researchers now call America's second largest threat to public health 

    Booth, Frank W., Ph. D.; Krupa, Donna J. (2001)
    Obesity has doubled, Type 2 diabetes has increased nine-fold, and heart disease remains the number one cause of death for Americans. Sedentary Death Syndrome, or "SeDS," is a growing list of health disorders that are ...

  • Cost and Consequences of Sedentary Living: New Battleground for an Old Enemy 

    Booth, Frank W., Ph. D.; Chakravarthy, Manu V. (2002)
    The purpose of this review is to update our earlier review by itemizing, as best we can, the costs and consequences of sedentary living, and thus provide cost reasons to fight a war against sedentary lifestyles.

  • Large Effects from Small Exposures. I. Mechanisms for Endocrine-Disrupting Chemicals with Estrogenic Activity 

    Welshons, Wade V.; Thayer, Kristina A. (Kristina Ann), 1969-; Judy, Barbara M.; Taylor, Julia A.; Curran, Edward M. (Edward Michael), 1949-; vom Saal, Frederick S. (National Institute of Environmental Health Sciences, 2003)
    Information concerning the fundamental mechanisms of action of both natural and environmental hormones, combined with information concerning endogenous hormone concentrations, reveals how endocrine-disrupting chemicals ...

  • Why Public Health Agencies Cannot Depend on Good Laboratory Practices as a Criterion for Selecting Data: The Case of Bisphenol A 

    Myers, John Peterson; vom Saal, Frederick S.; Akingbemi, Benson T.; Arizono, Koji; Belcher, Scott; Colborn, Theo; Chahoud, Ibrahim; Crain, D. Andrew, 1970-; Farabollini, Francesca; Guillette, Louis J., 1954-; Hassold, Terry J.; Ho, Shuk-mei; Hunt, Patricia A.; Iguchi, Taisen, 1951-; Jobling, Susan; Kanno, Jun; Laufer, Hans, 1929-; Marcus, Michele; McLachlan, John A.; Nadal, Angel; Oehlmann, Jörg; Olea, Nicolás; Palanza, Paola; Parmigiani, Stefano; Rubin, Beverly S.; Schoenfelder, Gilbert; Sonnenschein, C. (Carlos); Soto, A. M. (Ana M.); Talsness, Chris E.; Taylor, Julia A.; Vandenberg, Laura N.; Vandenbergh, John G.; Vogel, Sarah; Watson, Cheryl S., 1950-; Welshons, Wade V.; Zoeller, R. Thomas (National Institute of Environmental Health Sciences, 2009)
    We reviewed differences between industry-funded GLP studies of BPA conducted by commercial laboratories for regulatory purposes and non-GLP studies conducted in academic and government laboratories to identify hazards and ...

  • Response 

    Welshons, Wade V.; Nagel, Susan C.; vom Saal, Frederick S. (National Institute of Environmental Health Sciences, 1998)
    Welshons et al. respond to Ashby and Odum regarding their experimental design research on fetal exposure to very low doses of the environmental estrogen bisphenol A.

  • Bisphenol A Data in NHANES Suggest Longer than Expected Half-Life, Substantial Nonfood Exposure, or Both 

    Stahlhut, Richard W.; Welshons, Wade V.; Swan, Shanna H. (National Institute of Environmental Health Sciences, 2009)
    It is commonly stated in the literature on human exposure to bisphenol A (BPA) that food is the predominant BPA exposure source, and that BPA is rapidly and completely cleared from the body. If this is correct, BPA levels ...

  • New Approaches for Estimating Risk from Exposure to Diethylstilbestrol 

    Cunha, Gerald R.; Forsberg, John-Gunnar, 1935-; Golden, Robert; Haney, Arthur; Iguchi, Taisen, 1951-; Newbold, Retha R.; Swan, Shanna H.; Welshons, Wade V. (The National Institute of Environmental Health Sciences, 1999)
    A subgroup from a National Institute of Environmental Health Sciences, workshop concerned with characterizing the effects of endocrine disruptors on human health at environmental exposure levels considered the question, ...

  • Bisphenol A Is Released from Used Polycarbonate Animal Cages into Water at Room Temperature 

    Howdeshell, Kembra L. (Kembra Lynne), 1968-; Peterman, Paul Herbert, 1948-; Judy, Barbara M.; Taylor, Julia A.; Orazio, Carl E.; Ruhlen, Rachel L.; vom Saal, Frederick S.; Welshons, Wade V. (Environmental Health Perspectives, 2003)
    Bisphenol A (BPA) is a monomer with estrogenic activity that is used in the production of food packaging, dental sealants, polycarbonate plastic, and many other products. The monomer has previously been reported to hydrolyze ...