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Bisphenol A Data in NHANES Suggest Longer than Expected Half-Life, Substantial Nonfood Exposure, or Both
(National Institute of Environmental Health Sciences, 2009)
It is commonly stated in the literature on human exposure to bisphenol A (BPA) that food is the predominant BPA exposure source, and that BPA is rapidly and completely cleared from the body. If this is correct, BPA levels ...
Large Effects from Small Exposures. I. Mechanisms for Endocrine-Disrupting Chemicals with Estrogenic Activity
(National Institute of Environmental Health Sciences, 2003)
Information concerning the fundamental mechanisms of action of both natural and environmental hormones, combined with information concerning endogenous hormone concentrations, reveals how endocrine-disrupting chemicals ...
Response
(National Institute of Environmental Health Sciences, 1998)
Welshons et al. respond to Ashby and Odum regarding their experimental design research on fetal exposure to very low doses of the environmental estrogen bisphenol A.
Bisphenol A Is Released from Used Polycarbonate Animal Cages into Water at Room Temperature
(Environmental Health Perspectives, 2003)
Bisphenol A (BPA) is a monomer with estrogenic activity that is used in the production of food packaging, dental sealants, polycarbonate plastic, and many other products. The monomer has previously been reported to hydrolyze ...
Cost and Consequences of Sedentary Living: New Battleground for an Old Enemy
(2002)
The purpose of this review is to update our earlier review by itemizing, as best we can, the costs and consequences of sedentary living, and thus provide cost reasons to fight a war against sedentary lifestyles.
Sedentary death syndrome is what researchers now call America's second largest threat to public health
(2001)
Obesity has doubled, Type 2 diabetes has increased nine-fold, and heart disease remains the number one cause of death for Americans. Sedentary Death Syndrome, or "SeDS," is a growing list of health disorders that are ...
New Approaches for Estimating Risk from Exposure to Diethylstilbestrol
(The National Institute of Environmental Health Sciences, 1999)
A subgroup from a National Institute of Environmental Health Sciences, workshop concerned with characterizing the effects of endocrine disruptors on human health at environmental exposure levels considered the question, ...
Why Public Health Agencies Cannot Depend on Good Laboratory Practices as a Criterion for Selecting Data: The Case of Bisphenol A
(National Institute of Environmental Health Sciences, 2009)
We reviewed differences between industry-funded GLP studies of BPA conducted by commercial laboratories for regulatory purposes and non-GLP studies conducted in academic and government laboratories to identify hazards and ...
Endurance exercise training does not limit coronary atherosclerosis in familial hypercholesterolemic swine
(American Physiological Society, 2019)
Human studies demonstrate that physical activity reduces both morbidity and mortality of coronary heart disease (CHD) including decreased progression and/or regression of CHD with life-style modification which includes ...
Rats selectively bred for high voluntary physical activity behavior are not protected from the deleterious metabolic effects of a Western diet when sedentary
(Oxford University Press, 2019)
Background: Physical activity and diet are well-established modifiable factors that influence chronic disease risk. We developed a selectively bred, polygenic model for high and low voluntary running (HVR and LVR, respectively) ...
APR-246 alone and in combination with a phosphatidylserine-targeting antibody inhibits lung metastasis of human triple-negative breast cancer cells in nude mice
(Dove Medical Press Ltd., 2019)
Background: Approximately 15-20 percent of all human breast cancers are classified as triple-negative because they lack estrogen and progesterone receptors and Her-2-neu, which are commonly targeted by chemotherapeutic ...
A BAC transgene expressing human CFTR under control of its regulatory elements rescues Cftr knockout mice
(Nature Publishing Group, 2019)
Small-molecule modulators of cystic fibrosis transmembrane conductance regulator (CFTR) biology show promise in the treatment of cystic fibrosis (CF). A Cftr knockout (Cftr KO) mouse expressing mutants of human CFTR would ...