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    Which drugs are best when aggressive Alzheimer's patients need medication?

    Mohundro, Brice L.
    Pope, Karla
    Shaw, Vincent
    Hitchcock, Kristin
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    [PDF] WhichDrugsAggressiveAlzheimers.pdf (184.4Kb)
    Date
    2010
    Format
    Article
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    Abstract
    Atypical antipsychotics are an effective short-term (6-12 weeks) treatment for aggressive behavior in patients with Alzheimer's disease because they consistently decrease aggression scores (strength of recommendation [SOR]: A, multiple randomized controlled trials [RCTs]). However, evidence of drug-related deaths in patients taking these drugs mandates weighing the benefits against the risks. SSRIs may be a safer, effective alternative (SOR: B, limited studies). Evidence for the efficacy of antiepileptic agents is conflicting (SOR: C, inconsistent patient-oriented evidence). Valproate is ineffective for treating aggression (SOR: C, very small RCT). No data exist to guide long-term medication use. All available studies lasted no longer than 12 weeks. Nonpharmacologic therapy should be the first-line treatment for aggression in patients with Alzheimer's disease. Consider drug therapy for patients who pose an imminent threat to themselves or others.
    URI
    http://hdl.handle.net/10355/8666
    Part of
    Journal of family practice, 59, no. 10 (October 2010): 595+.
    Rights
    OpenAccess.
    This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License.
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    • Clinical Inquiries, 2010

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