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    Estradiol and Bisphenol A Stimulate Androgen Receptor and Estrogen Receptor Gene Expression in Fetal Mouse Prostate Mesenchyme Cells

    Richter, Catherine A.
    Taylor, Julia A.
    Ruhlen, Rachel L.
    vom Saal, Frederick S.
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    [PDF] EstradiolBisphenolAStimulateAndrogenReceptor.pdf (141.4Kb)
    Date
    2007
    Format
    Article
    Metadata
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    Abstract
    Hormonal alterations during development have lifelong effects on the prostate gland. Endogenous estrogens, including 17β-estradiol (E2), and synthetic estrogenic endocrine disruptors, such as bisphenol A (BPA), have similar effects on prostate development. Increasing exposure to estrogens within the low-dose, physiologic range results in permanent increases in the size and androgen responsiveness of the prostate, whereas exposure within the high-dose, pharmacologic range has the opposite effects.
    URI
    http://hdl.handle.net/10355/8675
    Part of
    Biological Sciences publications (MU)
    Citation
    Environmental Health Perspectives, 115(6), 2007.
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    • Biological Sciences publications (MU)

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