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dc.contributor.authorWalker, Angela Marie, 1978-eng
dc.contributor.authorRoberts, R. M. (Robert Michael), 1940-eng
dc.date.issued2009-04eng
dc.descriptiondoi:10.1186/1471-2164-10-187eng
dc.description.abstractThe Type I interferons (IFN) have major roles in the innate immune response to viruses, a function that is believed to have led to expansion in the number and complexity of their genes, although these genes have remained confined to single chromosomal region in all mammals so far examined. IFNB and IFNE define the limits of the locus, with all other Type I IFN genes except IFNK distributed between these boundaries, strongly suggesting that the locus has broadened as IFN genes duplicated and then evolved into a series of distinct families. We have provided the first comprehensive annotation of the Type I IFN locus in Bos taurus, thereby providing an insight into the functional evolution of the Type I IFN in ruminants. The diversity and global spread of the ruminant species may have required an expansion of the Type I IFN locus and its constituent genes to provide broad anti-viral protection required for foraging and foregut fermentation.eng
dc.description.sponsorshipNIH grant HD21896eng
dc.identifier.citationBMC Genomics, 10(187), 2009.eng
dc.identifier.urihttp://hdl.handle.net/10355/8772eng
dc.languageEnglisheng
dc.publisherBMC Genomicseng
dc.relation.ispartofVeterinary Pathobiology publications (MU)eng
dc.relation.ispartofcommunityUniversity of Missouri-Columbia. College of Veterinary Medicine. Department of Veterinary Pathobiologyeng
dc.source.harvestedBioMed Centraleng
dc.source.urihttp://www.biomedcentral.com/content/pdf/1471-2164-10-187.pdfeng
dc.subjectimmune defense systemeng
dc.subjectbovine genome assemblyeng
dc.subjectadaptive immunityeng
dc.subjectmammalian healtheng
dc.subject.lcshGenomicseng
dc.subject.lcshCattle -- Functional genomicseng
dc.subject.lcshViruses -- Evolutioneng
dc.titleCharacterization of the Bovine Type I IFN Locus: Rearrangements, Expansions, and Novel Subfamilieseng
dc.typeArticleeng


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