Characterization of the Bovine Type I IFN Locus: Rearrangements, Expansions, and Novel Subfamilies

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Characterization of the Bovine Type I IFN Locus: Rearrangements, Expansions, and Novel Subfamilies

Please use this identifier to cite or link to this item: http://hdl.handle.net/10355/8772

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dc.contributor.author Walker, Angela Marie, 1978-
dc.contributor.author Roberts, R. M. (Robert Michael), 1940-
dc.date.accessioned 2010-10-12T18:37:21Z
dc.date.available 2010-10-12T18:37:21Z
dc.date.issued 2009-04-24
dc.identifier.citation BMC Genomics, 10(187), 2009. en_US
dc.identifier.uri http://hdl.handle.net/10355/8772
dc.description doi:10.1186/1471-2164-10-187 en_US
dc.description.abstract The Type I interferons (IFN) have major roles in the innate immune response to viruses, a function that is believed to have led to expansion in the number and complexity of their genes, although these genes have remained confined to single chromosomal region in all mammals so far examined. IFNB and IFNE define the limits of the locus, with all other Type I IFN genes except IFNK distributed between these boundaries, strongly suggesting that the locus has broadened as IFN genes duplicated and then evolved into a series of distinct families. We have provided the first comprehensive annotation of the Type I IFN locus in Bos taurus, thereby providing an insight into the functional evolution of the Type I IFN in ruminants. The diversity and global spread of the ruminant species may have required an expansion of the Type I IFN locus and its constituent genes to provide broad anti-viral protection required for foraging and foregut fermentation. en_US
dc.description.sponsorship NIH grant HD21896
dc.language.iso en_US en_US
dc.publisher BMC Genomics en_US
dc.relation.ispartof Veterinary Pathobiology publications (MU) en_US
dc.source.uri http://www.biomedcentral.com/content/pdf/1471-2164-10-187.pdf
dc.subject immune defense system en_US
dc.subject bovine genome assembly en_US
dc.subject adaptive immunity en_US
dc.subject mammalian health en_US
dc.subject.lcsh Genomics
dc.subject.lcsh Cattle -- Functional genomics
dc.subject.lcsh Viruses -- Evolution
dc.title Characterization of the Bovine Type I IFN Locus: Rearrangements, Expansions, and Novel Subfamilies en_US
dc.type Article en_US
dc.source.harvested BioMed Central en_US
dc.relation.ispartofcommunity University of Missouri-Columbia. College of Veterinary Medicine. Department of Veterinary Pathobiology


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