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dc.contributor.authorWalker, Angela Marie, 1978-
dc.contributor.authorRoberts, R. M. (Robert Michael), 1940-
dc.date.issued2009-04eng
dc.descriptiondoi:10.1186/1471-2164-10-187en_US
dc.description.abstractThe Type I interferons (IFN) have major roles in the innate immune response to viruses, a function that is believed to have led to expansion in the number and complexity of their genes, although these genes have remained confined to single chromosomal region in all mammals so far examined. IFNB and IFNE define the limits of the locus, with all other Type I IFN genes except IFNK distributed between these boundaries, strongly suggesting that the locus has broadened as IFN genes duplicated and then evolved into a series of distinct families. We have provided the first comprehensive annotation of the Type I IFN locus in Bos taurus, thereby providing an insight into the functional evolution of the Type I IFN in ruminants. The diversity and global spread of the ruminant species may have required an expansion of the Type I IFN locus and its constituent genes to provide broad anti-viral protection required for foraging and foregut fermentation.en_US
dc.description.sponsorshipNIH grant HD21896
dc.identifier.citationBMC Genomics, 10(187), 2009.en_US
dc.identifier.urihttp://hdl.handle.net/10355/8772
dc.publisherBMC Genomicsen_US
dc.relation.ispartofVeterinary Pathobiology publications (MU)en_US
dc.relation.ispartofcommunityUniversity of Missouri-Columbia. College of Veterinary Medicine. Department of Veterinary Pathobiology
dc.source.harvestedBioMed Centralen_US
dc.source.urihttp://www.biomedcentral.com/content/pdf/1471-2164-10-187.pdf
dc.subjectimmune defense systemen_US
dc.subjectbovine genome assemblyen_US
dc.subjectadaptive immunityen_US
dc.subjectmammalian healthen_US
dc.subject.lcshGenomics
dc.subject.lcshCattle -- Functional genomics
dc.subject.lcshViruses -- Evolution
dc.titleCharacterization of the Bovine Type I IFN Locus: Rearrangements, Expansions, and Novel Subfamiliesen_US
dc.typeArticleen_US


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