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dc.contributor.advisorRafiee, Mohammad
dc.contributor.authorMayer, Mikayla Noelle
dc.date.issued2021
dc.date.submitted2021 Fall
dc.descriptionTitle from PDF of title page viewed January 20, 2022
dc.descriptionThesis advisor: Mohammad Rafiee
dc.descriptionVita
dc.descriptionIncludes bibliographical references (page 61-64)
dc.descriptionThesis (M.S.)--Department of Chemistry. University of Missouri--Kansas City, 2021
dc.description.abstractBlood alcohol concentration (BAC) is the indicator of alcohol intoxication, and its measurement has emerged as the most common analytical procedure requested by law enforcement. Due to its volatility, ethanol vapor can be detected in breath, and its vapor concentration is proportional to BAC. While portable breathalyzers have been designed for simple breath alcohol concentration detection, they are limited by high cost or the need for frequent recalibration. The first chapter of this thesis discusses the instrumentation used currently for alcohol detection, as well as the few recent attempts to improve the current methods of alcohol detection by adopting enzymatic detection methods. Although promising advancements have been made, the instability and high cost of enzymes prevent their commercial application. Chapter three describes how the unique catalytic activity of the aminoxyl radical/oxoammonium redox couple toward alcohol oxidation was harnessed for fabrication of an electrochemical ethanol sensor for breath analysis with experimental details described in chapter two. Our functional sensing element consists of a screen-printed electrode in which the graphene oxide-based working electrode is modified with aminoxyl derivatives, of which 4-hydroxy-2,2,6,6-tetramethylpiperidine 1-oxyl benzoate (TMB) was the most efficient derivative. Exposing this modified electrode to simulated breath that contains ethanol, while applying the required potential for oxidation of the aminoxyl radical, generates an electrocatalytic current proportional to the ethanol concentration in the breath. These simple, sensitive, durable, and inexpensive electrodes may contribute to the development of a single- use reliable ethanol sensor for personal or law enforcement applications.
dc.description.tableofcontentsIntroduction and background -- Experimental -- Results and discussion -- Conclusion and outlook
dc.format.extentxiii, 65 pages
dc.identifier.urihttps://hdl.handle.net/10355/88645
dc.subject.lcshBreath tests
dc.subject.lcshBlood alcohol -- Analysis
dc.subject.otherThesis -- University of Missouri--Kansas City -- Chemistry
dc.titleAminoxyl Catalyzed Electrochemical Ethanol Detection: Development of a New Breathalyzer Using Molecular Catalysis
thesis.degree.disciplineChemistry (UMKC)
thesis.degree.grantorUniversity of Missouri--Kansas City
thesis.degree.levelMasters
thesis.degree.nameM.S. (Master of Science)


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