dc.contributor.advisor | Laughlin, M. Harold | eng |
dc.contributor.author | Bunker, Aaron Kristopher, 1982- | eng |
dc.date.issued | 2010 | eng |
dc.date.submitted | 2010 Summer | eng |
dc.description | The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. | eng |
dc.description | Title from PDF of title page (University of Missouri--Columbia, viewed on November 9, 2010). | eng |
dc.description | "July 2010" | eng |
dc.description | Vita. | eng |
dc.description | Thesis advisor: M. Harold Laughlin. | eng |
dc.description | Ph. D. University of Missouri-Columbia 2010. | eng |
dc.description.abstract | [ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Physical inactivity due to increases in modern conveniences and access to cheap, high calorie foods have greatly contributed to the "obesity epidemic" frequently discussed in society today. Health consequences associated with obesity such as Type II diabetes (T2DM), metabolic syndrome, coronary artery disease (CAD), etc., greatly increase the morbidity and mortality rates in those constituting the obesity epidemic. Angiopathy is one of the putative primary causes of the morbidity and mortality in subjects with T2DM and CAD. Loss of the regulatory role of the vascular endothelium is a crucial initiating factor in the development of T2DM angiopathy and CAD. Consequently, understanding the physiological ramifications and underlying mechanisms for vascular dysfunction resulting from these disease states is essential for their treatment and prevention. Numerous studies exist highlighting the importance of regular physical activity and exercise on prevention of T2DM angiopathy and CAD. The following studies were conducted to investigate: Chapters 1-2) the effect of physical inactivity on vascular function and proteins during T2DM disease progression; Chapters 3-4) the effect of adipose tissue on vascular function in a CAD model; and Chapter 6) (supplemental) brief discussion on vascular function responses to angiotensin II in T2DM and role of superoxide in T2DM angiopathy. | eng |
dc.description.bibref | Includes bibliographical references. | eng |
dc.format.extent | xxi, 198 pages | eng |
dc.identifier.merlin | b80594736 | eng |
dc.identifier.oclc | 680033922 | eng |
dc.identifier.uri | https://hdl.handle.net/10355/9009 | |
dc.identifier.uri | https://doi.org/10.32469/10355/9009 | eng |
dc.language | English | eng |
dc.publisher | University of Missouri--Columbia | eng |
dc.relation.ispartofcommunity | University of Missouri--Columbia. Graduate School. Theses and Dissertations | eng |
dc.rights | Access is limited to the campus of the University of Missouri-Columbia. | eng |
dc.rights.license | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License. | |
dc.subject.lcsh | Obesity -- Complications | eng |
dc.subject.lcsh | Coronary heart disease -- Etiology | eng |
dc.subject.lcsh | Diabetic angiopathies -- Etiology | eng |
dc.subject.lcsh | Adipose tissue | eng |
dc.subject.lcsh | Exercise | eng |
dc.subject.lcsh | Angiotensin II | eng |
dc.subject.lcsh | Superoxide | eng |
dc.title | Vascular maladaptations to chronic disease and physical inactivity | eng |
dc.type | Thesis | eng |
thesis.degree.discipline | Veterinary biomedical sciences (MU) | eng |
thesis.degree.grantor | University of Missouri--Columbia | eng |
thesis.degree.level | Doctoral | eng |
thesis.degree.name | Ph. D. | eng |