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dc.contributor.advisorThyfault, John P.eng
dc.contributor.authorBorengasser, Sarah Jean, 1978-eng
dc.date.issued2010eng
dc.date.submitted2010 Summereng
dc.descriptionTitle from PDF of title page (University of Missouri--Columbia, viewed on August 25, 2010).eng
dc.descriptionThe entire thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file; a non-technical public abstract appears in the public.pdf file.eng
dc.descriptionDissertation advisor: Dr. John P. Thyfault.eng
dc.descriptionVita.eng
dc.descriptionPh. D. University of Missouri--Columbia 2010.eng
dc.description.abstract[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] The purpose of this study was to examine the individual and combined effects of exercise and dietary consumption of n3PUFAs as treatments for NAFLD. Otsuka Long-Evans Tokushima Fatty (OLETF) rats were studied due to their spontaneous development of obesity, insulin resistance, and NAFLD. A novelty of these rats is their intrinsic aptitude for voluntary wheel running despite their obesity. OLETFs were randomly divided into 4 groups (n=8/group): 1) remained sedentary 2) access to running wheels (3) diet supplemented with 3% of energy from fish oil and 4) access to running wheels and diet supplemented with 3% of energy from fish oil. Treatments began at 13 wk of age, an age when NAFLD is present in OLETF-SED rats, and lasted until all rats were sacrificed at 20 wk of age. Exercise appears to be more effective treatment for NAFLD in obese OLETF rats in part through increasing complete hepatic FAO, improving IS, and decreasing activation of the lipid synthesis pathway. Contrary to our original hypothesis, a diet moderately high in n3PUFAs failed to lower hepatic fat content and partially blunted the beneficial effects of exercise as a treatment strategy for NAFLD and systemic insulin resistance.eng
dc.description.bibrefIncludes bibliographical references.eng
dc.format.extentviii, 182 pageseng
dc.identifier.merlinb80593586eng
dc.identifier.oclc677928427eng
dc.identifier.urihttps://hdl.handle.net/10355/9015
dc.identifier.urihttps://doi.org/10.32469/10355/9015eng
dc.languageEnglisheng
dc.publisherUniversity of Missouri--Columbiaeng
dc.relation.ispartofcommunityUniversity of Missouri--Columbia. Graduate School. Theses and Dissertationseng
dc.rightsAccess is limited to the campus of the University of Missouri-Columbia.eng
dc.rights.licenseThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License.
dc.subjecthepatic steatosis ; non-alcoholic fatty liver diseaseeng
dc.subject.lcshFatty liver -- Diet therapyeng
dc.subject.lcshFatty liver -- Exercise therapyeng
dc.subject.lcshLiver -- Diseases -- Diet therapyeng
dc.subject.lcshLiver -- Diseases -- Exercise therapyeng
dc.subject.lcshOmega-3 fatty acidseng
dc.titleThe effects of exercise and omega-3 fatty acid supplementation as treatments for hepatic steatosiseng
dc.typeThesiseng
thesis.degree.disciplineNutrition area program (MU)eng
thesis.degree.grantorUniversity of Missouri--Columbiaeng
thesis.degree.levelDoctoraleng
thesis.degree.namePh. D.eng


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