Transillumination Optical Tomography of Tissue-Engineered Blood Vessels: A Monte Carlo Simulation

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Transillumination Optical Tomography of Tissue-Engineered Blood Vessels: A Monte Carlo Simulation

Please use this identifier to cite or link to this item: http://hdl.handle.net/10355/9028

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Title: Transillumination Optical Tomography of Tissue-Engineered Blood Vessels: A Monte Carlo Simulation
Author: Yao, Gang, Ph. D.; Haidekker, Mark A., 1963-
Date: 2005-07-10
Publisher: The Optical Society of America
Citation: Applied Optics, Vol. 44, Issue 20, pp. 4265-4271 (2005).
Abstract: A Monte Carlo technique has been developed to simulate the transillumination laser computed tomography of tissue-engineered blood vessels. The blood vessel was modeled as a single cylinder layer mounted on a tubular mandrel. Sequences of images were acquired while rotating the mandrel. The tomographic image was reconstructed by applying a standard Radon transform. Angular discrimination was applied to simulate a spatial filter, which was used to reject multiply scattered photons. The simulation results indicated that the scattering effect can be overcome with angular discrimination because of the thin tissue thickness. However, any refractive-index mismatch among the tissue, the surrounding media, and the mandrel could produce significant distortions in the reconstructed image.
URI: http://hdl.handle.net/10355/9028
ISSN: 0003-6935/05/204265-07$15.00/0

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