Shared more. Cited more. Safe forever.
    • advanced search
    • submit works
    • about
    • help
    • contact us
    • login
    View Item 
    •   MOspace Home
    • University of Missouri-Columbia
    • Office of Undergraduate Research (MU)
    • Undergraduate Research and Creative Achievements Forum (MU)
    • 2006 Undergraduate Research and Creative Achivements Forum (MU)
    • View Item
    •   MOspace Home
    • University of Missouri-Columbia
    • Office of Undergraduate Research (MU)
    • Undergraduate Research and Creative Achievements Forum (MU)
    • 2006 Undergraduate Research and Creative Achivements Forum (MU)
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.
    advanced searchsubmit worksabouthelpcontact us

    Browse

    All of MOspaceCommunities & CollectionsDate IssuedAuthor/ContributorTitleSubjectIdentifierThesis DepartmentThesis AdvisorThesis SemesterThis CollectionDate IssuedAuthor/ContributorTitleSubjectIdentifierThesis DepartmentThesis AdvisorThesis Semester

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular AuthorsStatistics by Referrer

    Estrogenic effects of polyphenols on ovariectomized rats [abstract]

    Bolden, Ashley
    View/Open
    [PDF] Estrogenic effects of polyphenols.pdf (14.68Kb)
    Date
    2006
    Contributor
    University of Missouri-Columbia. Office of Undergraduate Research
    Format
    Presentation
    Metadata
    [+] Show full item record
    Abstract
    In this study we tested the estrogenic potential of certain polyphenols administered in the diet to ovariectomized female Sprague Dawley rats. One week after ovariectomy, five week old rats were placed on one of the following treatments: epigallocatechin gallate (EGCG), resveratrol, genistein, daidzein (all at 250 mg/kg AIN- 93M diet), estradiol benzoate (EB) (at 50 ug/kg diet), or a control diet (AIN-93M). After 14 days of dietary treatment, the rats were sacrificed and their uteri were dissected for analysis by uterine to body weight ratios and immunoblotting. The average body weights for the treatment groups were statistically consistent except for estradiol benzoate, which had a slight but significantly decreased body weight compared to the other treatments. The data for uterine to body weight ratios showed that the sham (ovary-intact), genistein, and EB groups were significantly increased compared to the ovariectomized control group. Immuno-blot analysis in the uterus for estrogen receptor alpha indicated a decrease in the protein expression in the sham and the EB groups, while the resveratrol, EGCG, and daidzein groups resulted in an increase in ER-alpha expression with respect to the control group. Progesterone receptor-b expression in the uterus was significantly increased following EB, daidzein,or EGCG treatments. This data suggests that estradiol benzoate and, to a lesser extent, genistein have estrogenic effects in the uterus and that the polyphenols EGCG, resveratrol, and daidzein are able to affect protein expressions via non-estrogen receptor mechanisms.
    URI
    http://hdl.handle.net/10355/905
    Collections
    • 2006 Undergraduate Research and Creative Achivements Forum (MU)

    Send Feedback
    hosted by University of Missouri Library Systems
     

     


    Send Feedback
    hosted by University of Missouri Library Systems