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dc.contributor.authorChanda, Nripeneng
dc.contributor.authorShukla, Ravieng
dc.contributor.authorKatti, Kattesh V.eng
dc.contributor.authorKannan, Raghuramaneng
dc.date.issued2009eng
dc.descriptionDOI: 10.1021/nl8037147eng
dc.description.abstractGastrin releasing protein receptor specific bombesin (BBN) peptide-gold nanoconjugates were successfully synthesized using gold nanorods and dithiolated peptide. The gold nanorod-bombesin (GNR-BBN) conjugates showed extraordinary in vitro stabilities against various biomolecules including NaCl, cysteine, histidine, bovine serum albumin, human serum albumin, and dithiothreitol. Quantitative measurements on the binding affinity (IC50) of GNR-BBN conjugates toward prostate and breast tumor cells were evaluated. The IC50 values establish that GNR-BBN conjugates have strong affinity toward the gastrin releasing peptide receptors on both the tumors. Detailed cellular interaction studies of GNR-BBN conjugates revealed that nanorods internalize via a receptor-mediated endocytosis pathway. The receptor specific interactions of GNR-BBN conjugates provide realistic opportunities in the design and development of in vivo molecular imaging and therapy agents for cancer.eng
dc.description.sponsorshipThis work has been supported by the National Institutes of Health/National Cancer Institute under the Cancer Nanotechnology Platform program and Nanoscience and Nanotechnology program (Grant Numbers 5R01CA119412-04 and 1R21CA128460-02).eng
dc.identifier.citationNano Lett., 2009, 9 (5), pp 1798-1805.eng
dc.identifier.issn1530-6984eng
dc.identifier.urihttp://hdl.handle.net/10355/9061eng
dc.languageEnglisheng
dc.publisherAmerican Chemical Societyeng
dc.relation.ispartofRadiology publications (MU)eng
dc.relation.ispartofcommunityUniversity of Missouri-Columbia. School of Medicine. Department of Radiologyeng
dc.source.urihttp://pubs.acs.org/eng
dc.subjectnanorodseng
dc.subjectmolecular imagingeng
dc.subjectGastrin releasing protein receptor specific bombesineng
dc.subject.lcshBreast -- Tumors -- Treatmenteng
dc.subject.lcshProstate -- Tumors -- Treatmenteng
dc.subject.lcshCancer -- Imagingeng
dc.subject.lcshNanoparticleseng
dc.titleGastrin Releasing Protein Receptor Specific Gold Nanorods: Breast and Prostate Tumor Avid Nanovectors for Molecular Imagingeng
dc.typeArticleeng


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